RNA world - the dark matter of evolutionary genomics

@article{citeulike:896228, abstract = {Abstract For a long time, molecular evolutionary biologists have been focused on DNA and proteins, whereas RNA has lived in the shadow of its famous chemical cousins as a mere intermediary. Although this perspective has begun to change since genome-wide transcriptional profiling was successfully extended to evolutionary biology, it still echoes in evolutionary literature. In this mini-review, new developments of RNA biochemistry and transcriptomics are brought to the attention of evolutionary biologists. In particular, the unexpected abundance and functional significance of noncoding RNAs is briefly reviewed. Noncoding RNAs control a remarkable range of biological pathways and processes, all with obvious fitness consequences, such as initiation of translation, mRNA abundance, transposon jumping, chromosome architecture, stem cell maintenance, development of brain and muscles, insulin secretion, cancerogenesis and plant resistance to viral infections.}, author = {Michalak, P. }, citeulike-article-id = {896228}, doi = {http://dx.doi.org/10.1111/j.1420-9101.2006.01141.x}, journal = {Journal of Evolutionary Biology}, keywords = {biology, evolution, rna, views}, number = {6}, pages = {1768--1774}, posted-at = {2006-10-20 13:19:24}, priority = {2}, title = {RNA world - the dark matter of evolutionary genomics}, url = {http://dx.doi.org/10.1111/j.1420-9101.2006.01141.x}, volume = {19}, year = {2006} }

TY - JOUR ID - citeulike:896228 L3 - citeulike-article-id:896228 TI - RNA world - the dark matter of evolutionary genomics JF - Journal of Evolutionary Biology VL - 19 IS - 6 SP - 1768 EP - 1774 N2 - Abstract For a long time, molecular evolutionary biologists have been focused on DNA and proteins, whereas RNA has lived in the shadow of its famous chemical cousins as a mere intermediary. Although this perspective has begun to change since genome-wide transcriptional profiling was successfully extended to evolutionary biology, it still echoes in evolutionary literature. In this mini-review, new developments of RNA biochemistry and transcriptomics are brought to the attention of evolutionary biologists. In particular, the unexpected abundance and functional significance of noncoding RNAs is briefly reviewed. Noncoding RNAs control a remarkable range of biological pathways and processes, all with obvious fitness consequences, such as initiation of translation, mRNA abundance, transposon jumping, chromosome architecture, stem cell maintenance, development of brain and muscles, insulin secretion, cancerogenesis and plant resistance to viral infections. KW - biology KW - evolution KW - rna KW - views AU - Michalak, P PY - 2006/// UR - http://dx.doi.org/10.1111/j.1420-9101.2006.01141.x ER -