Transcranial magnetic stimulation elicits coupled neural and hemodynamic consequences.

@article{citeulike:2306219, abstract = {Transcranial magnetic stimulation (TMS) is an increasingly common technique used to selectively modify neural processing. However, application of TMS is limited by uncertainty concerning its physiological effects. We applied TMS to the cat visual cortex and evaluated the neural and hemodynamic consequences. Short TMS pulse trains elicited initial activation (~1 minute) and prolonged suppression (5 to 10 minutes) of neural responses. Furthermore, TMS disrupted the temporal structure of activity by altering phase relationships between neural signals. Despite the complexity of this response, neural changes were faithfully reflected in hemodynamic signals; quantitative coupling was present over a range of stimulation parameters. These results demonstrate long-lasting neural responses to TMS and support the use of hemodynamic-based neuroimaging to effectively monitor these changes over time.}, author = {Allen, E. A. and Pasley, B. N. and Duong, T. and Freeman, R. D. }, citeulike-article-id = {2306219}, journal = {Science}, keywords = {cogneuro\_spring2008}, month = {September}, number = {5846}, pages = {1918--1921}, posted-at = {2008-02-09 00:24:16}, priority = {3}, title = {Transcranial magnetic stimulation elicits coupled neural and hemodynamic consequences.}, volume = {317}, year = {2007} }

TY - JOUR ID - citeulike:2306219 L3 - citeulike-article-id:2306219 TI - Transcranial magnetic stimulation elicits coupled neural and hemodynamic consequences. JF - Science VL - 317 IS - 5846 SP - 1918 EP - 1921 N2 - Transcranial magnetic stimulation (TMS) is an increasingly common technique used to selectively modify neural processing. However, application of TMS is limited by uncertainty concerning its physiological effects. We applied TMS to the cat visual cortex and evaluated the neural and hemodynamic consequences. Short TMS pulse trains elicited initial activation (~1 minute) and prolonged suppression (5 to 10 minutes) of neural responses. Furthermore, TMS disrupted the temporal structure of activity by altering phase relationships between neural signals. Despite the complexity of this response, neural changes were faithfully reflected in hemodynamic signals; quantitative coupling was present over a range of stimulation parameters. These results demonstrate long-lasting neural responses to TMS and support the use of hemodynamic-based neuroimaging to effectively monitor these changes over time. KW - cogneuro_spring2008 AU - Allen, EA AU - Pasley, BN AU - Duong, T AU - Freeman, RD PY - 2007/09/28/ ER -