Remediation of Sleep-Deprivation-Induced Working Memory Impairment with fMRI-Guided Transcranial Magnetic Stimulation.

@article{citeulike:2304498, abstract = {Repetitive transcranial magnetic stimulation (rTMS) was applied to test the role of selected cortical regions in remediating sleep-deprivation-induced deficits in visual working memory (WM) performance. Three rTMS targets were chosen using a functional magnetic resonance imaging (fMRI)-identified network associated with sleep-deprivation-induced WM performance impairment: 2 regions from the network (upper left middle occipital gyrus and midline parietal cortex) and 1 nonnetwork region (lower left middle occipital gyrus). Fifteen participants underwent total sleep deprivation for 48 h. rTMS was applied at 5 Hz during a WM task in a within-subject sham-controlled design. The rTMS to the upper-middle occipital site resulted in a reduction of the sleep-induced reaction time deficit without a corresponding decrease in accuracy, whereas stimulation at the other sites did not. Each subject had undergone fMRI scanning while performing the task both pre- and postsleep deprivation, and the degree to which each individual activated the fMRI network was measured. The degree of performance enhancement with upper-middle occipital rTMS correlated with the degree to which each individual failed to sustain network activation. No effects were found in a subset of participants who performed the same rTMS procedure after recovering from sleep deprivation, suggesting that the performance enhancements seen following sleep deprivation were state dependent.}, address = {Division of Brain Stimulation and Therapeutic Modulation, New York State Psychiatric Institute, NY 10032, USA.}, author = {Luber, B and Stanford, A D D. and Bulow, P and Nguyen, T and Rakitin, B C C. and Habeck, C and Basner, R and Stern, Y and Lisanby, S H H. }, citeulike-article-id = {2304498}, issn = {1460-2199}, journal = {Cereb Cortex}, keywords = {kristina, memory, nichola, sleep, tms}, month = {January}, posted-at = {2008-01-29 16:39:32}, priority = {2}, title = {Remediation of Sleep-Deprivation-Induced Working Memory Impairment with fMRI-Guided Transcranial Magnetic Stimulation.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18203694}, year = {2008} }

TY - JOUR ID - citeulike:2304498 L3 - citeulike-article-id:2304498 TI - Remediation of Sleep-Deprivation-Induced Working Memory Impairment with fMRI-Guided Transcranial Magnetic Stimulation. JF - Cereb Cortex AD - Division of Brain Stimulation and Therapeutic Modulation, New York State Psychiatric Institute, NY 10032, USA. SN - 1460-2199 N2 - Repetitive transcranial magnetic stimulation (rTMS) was applied to test the role of selected cortical regions in remediating sleep-deprivation-induced deficits in visual working memory (WM) performance. Three rTMS targets were chosen using a functional magnetic resonance imaging (fMRI)-identified network associated with sleep-deprivation-induced WM performance impairment: 2 regions from the network (upper left middle occipital gyrus and midline parietal cortex) and 1 nonnetwork region (lower left middle occipital gyrus). Fifteen participants underwent total sleep deprivation for 48 h. rTMS was applied at 5 Hz during a WM task in a within-subject sham-controlled design. The rTMS to the upper-middle occipital site resulted in a reduction of the sleep-induced reaction time deficit without a corresponding decrease in accuracy, whereas stimulation at the other sites did not. Each subject had undergone fMRI scanning while performing the task both pre- and postsleep deprivation, and the degree to which each individual activated the fMRI network was measured. The degree of performance enhancement with upper-middle occipital rTMS correlated with the degree to which each individual failed to sustain network activation. No effects were found in a subset of participants who performed the same rTMS procedure after recovering from sleep deprivation, suggesting that the performance enhancements seen following sleep deprivation were state dependent. KW - kristina KW - memory KW - nichola KW - sleep KW - tms AU - Luber, B AU - Stanford, A D AU - Bulow, P AU - Nguyen, T AU - Rakitin, B C AU - Habeck, C AU - Basner, R AU - Stern, Y AU - Lisanby, S H PY - 2008/01/17/ UR - http://view.ncbi.nlm.nih.gov/pubmed/18203694 ER -