Sun, 27 Jul 2008 11:02:36 BST CiteULike: Author Manica http://www.citeulike.org/author/Manica CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/jyuh/article/1095215 <i>Nature</i> An African origin for the intimate association between humans and Helicobacter pylori Bodo Linz François Balloux Yoshan Moodley Andrea Manica Hua Liu Philippe Roumagnac Daniel Falush Christiana Stamer Franck Prugnolle Schalk van der Merwe Yoshio Yamaoka David Graham Emilio Perez-Trallero Torkel Wadstrom Sebastian Suerbaum Mark Achtman doi:10.1038/nature05562 Nature 2007-02-08T19:36:11-00:00 Nature 0028-0836 Nature Publishing Group no-tag http://www.citeulike.org/user/balicea/article/1465869 <i>Nature, Vol. 448, No. 7151., pp. 346-348.</i> The effect of ancient population bottlenecks on human phenotypic variation Andrea Manica William Amos François Balloux Tsunehiko Hanihara doi:10.1038/nature05951 Nature, Vol. 448, No. 7151., pp. 346-348. 2007-07-18T23:12:57-00:00 Nature 0028-0836 448 7151 346 348 Nature Publishing Group anthropometry cultural-evolution evolution evolutionary-genomics evolution-of-intelligence genome-variation pop-gen http://www.citeulike.org/user/joepickrell/article/1577030 <i>Trends in Genetics, Vol. 23, No. 9. (September 2007), pp. 432-439.</i><br /><br />Global human genetic variation is greatly influenced by geography, with genetic differentiation between populations increasing with geographic distance and within-population diversity decreasing with distance from Africa. In fact, these 'clines' can explain most of the variation in human populations. Despite this, population genetics inferences often rely on models that do not take geography into account, which could result in misleading conclusions when working at global geographic scales. Geographically explicit approaches have great potential for the study of human population genetics. Here, we discuss the most promising avenues of research in the context of human settlement history and the detection of genomic elements under natural selection. We also review recent technical advances and address the challenges of integrating geography and genetics. Going the distance: human population genetics in a clinal world Lori Handley Andrea Manica Jerome Goudet Francois Balloux doi:10.1016/j.tig.2007.07.002 Trends in Genetics, Vol. 23, No. 9. (September 2007), pp. 432-439. 2007-08-20T15:38:14-00:00 2007 Trends in Genetics 23 9 432 439 genetics population http://www.citeulike.org/user/ryanraaum/article/1552512 <i>Human Genetics, Vol. 118, No. 3. (18 December 2005), pp. 366-371.</i><br /><br />Abstract Individuals differ genetically in their susceptibility to particular diseases and their response to drugs. However, personalized treatments are difficult to develop, because disease susceptibility and drug response generally have poorly characterized genetic architecture. It is thus tempting to use the ethnicity of patients to capture some of the variation in allele frequencies at the genes underlying a clinical trait. The success of such a strategy depends on whether human populations can be accurately classified into discrete genetic ethnic groups. Despite the heated discussions and controversies surrounding this issue, there has been essentially no attempt so far to quantify the relative power of ethnic groups and geography at predicting the proportion of shared alleles between human populations. Here, we present the first such quantification using a dataset of 51 populations typed at 377 autosomal microsatellite markers, and show that pair-wise geographic distances across landmasses constitute a far better predictor than ethnicity. Allele-sharing between human populations worldwide decays smoothly with increasing physical distance. We discuss the relevance of these patterns for the expected distribution of variants of medical interest. The distribution patterns of gene coding for simple traits are expected to be highly heterogeneous, as most such genes experienced strong natural selection. However, variants involved in complex traits are expected to behave essentially neutrally, and we expect them to fit closely our predictions based on microsatellites. We conclude that the use of ethnicity alone will often be inadequate as a basis for medical treatment. Geography is a better determinant of human genetic differentiation than ethnicity Andrea Manica Franck Prugnolle François Balloux doi:10.1007/s00439-005-0039-3 Human Genetics, Vol. 118, No. 3. (18 December 2005), pp. 366-371. 2007-08-10T20:34:38-00:00 2005 Human Genetics 118 3 366 371 geographic-structure population-structure race str http://www.citeulike.org/user/lp2/article/1468558 <i>Current Biology, Vol. 15, No. 5. (8 March 2005), pp. R159-R160.</i><br /><br />A leading theory for the origin of modern humans, the `recent African origin' (RAO) model [], postulates that the ancestors of all modern humans originated in East Africa and that, around 100,000 years ago, some modern humans left the African continent and subsequently colonised the entire world, displacing previously established human species such as Neanderthals in Europe [ and ]. This scenario is supported by the observation that human populations from Africa are genetically the most diverse [] and that the genetic diversity of non-African populations is negatively correlated with their genetic differentiation towards populations from Africa []. Geography predicts neutral genetic diversity of human populations Franck Prugnolle Andrea Manica Francois Balloux Current Biology, Vol. 15, No. 5. (8 March 2005), pp. R159-R160. 2007-07-20T09:56:59-00:00 2005 Current Biology 15 5 R159 R160 no-tag http://www.citeulike.org/user/ladygoat/article/139226 <i>Curr Biol, Vol. 15, No. 5. (8 March 2005)</i> Geography predicts neutral genetic diversity of human populations. F Prugnolle A Manica F Balloux doi:10.1016/j.cub.2005.02.038 Curr Biol, Vol. 15, No. 5. (8 March 2005) 2005-03-24T15:45:06-00:00 2005 Curr Biol 0960-9822 15 5 no-tag