Wed, 20 Aug 2008 21:22:48 BST CiteULike: jayster4 Baehner http://www.citeulike.org/user/jayster4/author/Baehner CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/jayster4/article/989152 <i>Cancer Cell, Vol. 10, No. 6. (December 2006), pp. 515-527.</i><br /><br />SummaryRecent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model "system" to appraise the functional contributions of these genes to breast cancer subsets. In general, the recurrent genomic and transcriptional characteristics of 51 breast cancer cell lines mirror those of 145 primary breast tumors, although some significant differences are documented. The cell lines that comprise the system also exhibit the substantial genomic, transcriptional, and biological heterogeneity found in primary tumors. We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Richard Neve Koei Chin Jane Fridlyand Jennifer Yeh Frederick Baehner Tea Fevr Laura Clark Nora Bayani Jean-Philippe Coppe Frances Tong doi:10.1016/j.ccr.2006.10.008 Cancer Cell, Vol. 10, No. 6. (December 2006), pp. 515-527. 2006-12-11T23:57:48-00:00 2006 Cancer Cell 10 6 515 527 breast_cancer