Thu, 21 Aug 2008 10:12:39 BST CiteULike: jyuh Bradáč http://www.citeulike.org/user/jyuh/author/Bradáč CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/jyuh/article/2273592 <i>Comput Methods Programs Biomed (18 January 2008)</i><br /><br />RNA interference (RNAi) has become an important tool to study and utilize gene silencing by introducing short interfering RNA (siRNA). In order to predict the most efficient siRNAs, a new software tool, RNA Workbench (RNAWB), has been designed and is freely available (after registration) on http://www.rnaworkbench.com. In addition to the standard selection rules, RNAWB includes the possibility of statistical analyses of the applied selection rules (criteria). The role of RNA secondary structures in the RNA interference process as well as the application of sequence rules are discussed to show the applicability of the software. www.rnaworkbench.com: A new program for analyzing RNA interference. Radka Svobodová Vařeková Ivan Bradáč Martin Plchút Michal Skrdla Michael Wacenovsky Helmuth Mahr Georg Mayer Herbert Tanner Hermann Brugger Josef Withalm Peter Lederer Heinrich Huber Gerhard Gierlinger Ronald Graf Hakim Tafer Ivo Hofacker Peter Schuster Martin Polčík doi:10.1016/j.cmpb.2007.12.001 Comput Methods Programs Biomed (18 January 2008) 2008-01-22T12:48:30-00:00 2008 Comput Methods Programs Biomed 0169-2607 rnai