Sat, 26 Jul 2008 08:42:14 BST CiteULike: nelmor Maquet http://www.citeulike.org/user/nelmor/author/Maquet CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/nelmor/article/2717522 <i>Neuron, Vol. 58, No. 2. (24 April 2008), pp. 261-272.</i><br /><br />Summary Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior. Both the Hippocampus and Striatum Are Involved in Consolidation of Motor Sequence Memory Geneviève Albouy Virginie Sterpenich Evelyne Balteau Gilles Vandewalle Martin Desseilles Thanh Dang-Vu Annabelle Darsaud Perrine Ruby Pierre-Hervé Luppi Christian Degueldre Philippe Peigneux André Luxen Pierre Maquet doi:10.1016/j.neuron.2008.02.008 Neuron, Vol. 58, No. 2. (24 April 2008), pp. 261-272. 2008-04-25T12:12:01-00:00 2008 Neuron 58 2 261 272 consolidation fmri hippocampus striatum