Thu, 21 Aug 2008 00:00:15 BST CiteULike: xingxu Greenwood http://www.citeulike.org/user/xingxu/author/Greenwood CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/xingxu/article/1507843 <i>Nature Genetics, Vol. 39, No. 8. (08 July 2007), pp. 989-994.</i> Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 Brent Zanke Celia Greenwood Jagadish Rangrej Rafal Kustra Albert Tenesa Susan Farrington James Prendergast Sylviane Olschwang Theodore Chiang Edgar Crowdy Vincent Ferretti Philippe Laflamme Saravanan Sundararajan Stéphanie Roumy Jean-François Olivier Frédérick Robidoux Robert Sladek Alexandre Montpetit Peter Campbell Stephane Bezieau Anne O'Shea George Zogopoulos Michelle Cotterchio Polly Newcomb John Mclaughlin Ban Younghusband Roger Green Jane Green Mary Porteous Harry Campbell Helene Blanche Mourad Sahbatou Emmanuel Tubacher Catherine Bonaiti-Pellié Bruno Buecher Elio Riboli Sebastien Kury Stephen Chanock John Potter Gilles Thomas Steven Gallinger Thomas Hudson Malcolm Dunlop doi:10.1038/ng2089 Nature Genetics, Vol. 39, No. 8. (08 July 2007), pp. 989-994. 2007-07-27T23:29:54-00:00 2007 Nature Genetics 1061-4036 39 8 989 994 Nature Publishing Group 8q24 colon gwa http://www.citeulike.org/user/xingxu/article/1529091 <i>Hum Genet (19 July 2007)</i><br /><br />Genomic copy number variation (CNV) is a recently identified form of global genetic variation in the human genome. The Affymetrix GeneChip 100 and 500 K SNP genotyping platforms were used to perform a large-scale population-based study of CNV frequency. We constructed a genomic map of 578 CNV regions, covering approximately 220 Mb (7.3%) of the human genome, identifying 183 previously unknown intervals. Copy number changes were observed to occur infrequently (<1%) in the majority (>93%) of these genomic regions, but encompass hundreds of genes and disease loci. This North American population-based map will be a useful resource for future genetic studies. Germ-line DNA copy number variation frequencies in a large North American population. George Zogopoulos Kevin Ha Faisal Naqib Sara Moore Hyeja Kim Alexandre Montpetit Frederick Robidoux Philippe Laflamme Michelle Cotterchio Celia Greenwood Stephen Scherer Brent Zanke Thomas Hudson Gary Bader Steven Gallinger doi:10.1007/s00439-007-0404-5 Hum Genet (19 July 2007) 2007-08-01T21:26:04-00:00 2007 Hum Genet 0340-6717 cnv