Mon, 07 Jul 2008 16:51:25 BST CiteULike: xingxu Piccolboni http://www.citeulike.org/user/xingxu/author/Piccolboni CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/xingxu/article/1336057 <i>Science (17 May 2007), 1138341.</i><br /><br />Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated and has reduced protein-coding potential. The genomic origins and the relations of human nuclear and cytosolic polyadenylated RNAs longer than 200 nucleotides and whole-cell RNAs less than 200 nt are investigated in this genome-wide study. Subcellular addresses for nucleotides present in detected RNAs were assigned, and their potential processing into short RNAs was investigated. Taken together, these observations suggest a role for some unannotated RNAs as primary transcripts for the production of short RNAs. Three novel potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes. These data support a highly interleaved organization of the human transcriptome. 10.1126/science.1138341 RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription Philipp Kapranov Jill Cheng Sujit Dike David Nix Radharani Duttagupta Aarron Willingham Peter Stadler Jana Hertel Joerg Hackermueller Ivo Hofacker Ian Bell Evelyn Cheung Jorg Drenkow Erica Dumais Sandeep Patel Gregg Helt Madhavan Ganesh Srinka Ghosh Antonio Piccolboni Victor Sementchenko Hari Tammana Thomas Gingeras doi:10.1126/science.1138341 Science (17 May 2007), 1138341. 2007-05-27T00:42:53-00:00 2007 Science 1138341 breakthrough methods transcriptome http://www.citeulike.org/user/xingxu/article/876191 <i>Nature Genetics, Vol. 38, No. 10. (03 September 2006), pp. 1151-1158.</i> Biological function of unannotated transcription during the early development of Drosophila melanogaster Robert Manak Sujit Dike Victor Sementchenko Philipp Kapranov Frederic Biemar Jeff Long Jill Cheng Ian Bell Srinka Ghosh Antonio Piccolboni Thomas Gingeras doi:10.1038/ng1875 Nature Genetics, Vol. 38, No. 10. (03 September 2006), pp. 1151-1158. 2006-09-28T09:22:15-00:00 2006 Nature Genetics 1061-4036 38 10 1151 1158 Nature Publishing Group affymetrix drosophila genomics race