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Ключевое слово ageing [122 articles]

Recent papers classified by the tag ageing.
  • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
    Genes Dev, Vol. 13, No. 19. (1 October 1999), pp. 2570-2580.
    by M Kaeberlein, M McVey, L Guarente
    posted to ageing sir2 by yedmonds on 2005-06-20 20:53:35 as **
  • Extension of life-span by introduction of telomerase into normal human cells.
    Science, Vol. 279, No. 5349. (16 January 1998), pp. 349-352.
    by AG Bodnar, M Ouellette, M Frolkis, SE Holt, CP Chiu, GB Morin, CB Harley, JW Shay, S Lichtsteiner, WE Wright
    posted to ageing telomerase by yedmonds on 2005-06-20 20:13:51 as ** along with 1 person aredash
  • Revisiting the role of fat mass in the life extension induced by caloric restriction.
    J Gerontol A Biol Sci Med Sci, Vol. 54, No. 3. (March 1999)
    by N Barzilai, G Gupta
    posted to adipocytes ageing cr by yedmonds on 2005-06-22 20:50:32 as **
  • New polymorphisms in the human poly(ADP-ribose) polymerase-1 coding sequence: lack of association with longevity or with increased cellular poly(ADP-ribosyl)ation capacity.
    J Mol Med, Vol. 78, No. 8. (2000), pp. 431-440.
    by F Cottet, H Blanché, P Verasdonck, I Le Gall, F Schächter, A Bürkle, ML Muiras
    posted to ageing par parp by yedmonds on 2005-06-20 16:53:08 as *
  • Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications.
    Mol Nutr Food Res, Vol. 49, No. 5. (May 2005), pp. 405-430.
    by CA de la Lastra, I Villegas
    posted to ageing inflammation resveratrol by yedmonds on 2005-06-22 13:51:05 as ***
  • Age-related alteration of poly(ADP-ribose) polymerase activity in different parts of the brain.
    Acta Biochim Pol, Vol. 47, No. 2. (2000), pp. 331-337.
    by JB Strosznajder, H Jeśko, RP Strosznajder
    posted to ageing brain parp by yedmonds on 2005-06-20 16:25:01 as **
  • Genetics and the specificity of the aging process.
    Science, Vol. 299, No. 5611. (28 February 2003), pp. 1351-1354.
    by S Hekimi, L Guarente
    posted to ageing by yedmonds on 2005-06-20 21:25:22 as ** along with 1 person and 1 group tharris C. elegans / WormBase
  • Role of oxidative stress in telomere length regulation and replicative senescence.
    Ann N Y Acad Sci, Vol. 908 (June 2000), pp. 99-110.
    by T von Zglinicki
    posted to ageing oxidativestress telomerase by yedmonds on 2005-06-20 20:28:49 as **
  • The new life of a centenarian: signalling functions of NAD(P).
    Trends Biochem Sci, Vol. 29, No. 3. (March 2004), pp. 111-118.
    by F Berger, MH Ramírez-Hernández, M Ziegler
    posted to ageing nadnadh nicotinamide oacetyladpr parp sir2 by yedmonds on 2005-06-20 21:20:02 as read
  • The role of fat depletion in the biological benefits of caloric restriction.
    J Nutr, Vol. 131, No. 3. (March 2001)
    by N Barzilai, I Gabriely
    posted to adipocytes ageing cr by yedmonds on 2005-06-22 20:53:37 as **
  • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
    Nature, Vol. 410, No. 6825. (8 March 2001), pp. 227-230.
    by HA Tissenbaum, L Guarente
    posted to ageing sir2 by yedmonds on 2005-06-20 20:54:20 as ** along with 1 person and 1 group tharris C. elegans / WormBase
  • Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide.
    Front Biosci, Vol. 9 (1 September 2004), pp. 2500-2520.
    by F Li, ZZ Chong, K Maiese
    posted to ageing nadnadh nicotinamide parp sir2 by yedmonds on 2005-06-22 14:25:40 as read
  • Defending genomic stability over life span: a proposed role for PARP-1.
    Exp Gerontol, Vol. 35, No. 6-7. (September 2000), pp. 703-709.
    by ML Muiras, A Bürkle
    posted to ageing genomicstability parp by yedmonds on 2005-06-20 15:48:22 as **
  • Human senescence.
    Bioessays, Vol. 18, No. 12. (December 1996), pp. 1009-1016.
    by TB Kirkwood
    posted to ageing by yedmonds on 2005-06-20 20:17:14 as ***
  • Stress, DNA damage and ageing -- an integrative approach.
    Exp Gerontol, Vol. 36, No. 7. (July 2001), pp. 1049-1062.
    by T von Zglinicki, A Bürkle, TB Kirkwood
    posted to ageing dnadamagerepair oxidativestress by yedmonds on 2005-06-20 20:11:51 as read
  • Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence.
    J Physiol Pharmacol, Vol. 56 Suppl 2 (March 2005), pp. 77-88.
    by J Wesierska-Gadek, C Ranftler, G Schmid
    posted to ageing p53 parp senescence by yedmonds on 2005-08-11 15:01:50 as read
  • Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts.
    J Gerontol A Biol Sci Med Sci, Vol. 53, No. 6. (November 1998)
    by G Saretzki, J Feng, T von Zglinicki, B Villeponteau
    posted to ageing oxidativestress by yedmonds on 2005-06-20 20:23:45 as *
  • The emerging role of poly(ADP-ribose) polymerase-1 in longevity.
    Int J Biochem Cell Biol, Vol. 37, No. 5. (May 2005), pp. 1043-1053.
    by A Bürkle, C Brabeck, J Diefenbach, S Beneke
    posted to ageing dnadamagerepair genomicstability parp wrn by yedmonds on 2005-06-20 20:02:22 as read
  • Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease.
    Curr Opin Cell Biol, Vol. 15, No. 2. (April 2003), pp. 241-246.
    by SJ Lin, L Guarente
    posted to ageing cr nadnadh silencing sir2 by yedmonds on 2005-06-20 20:47:21 as read
  • Molecular mechanisms of yeast aging.
    Trends Biochem Sci, Vol. 23, No. 4. (April 1998), pp. 131-134.
    by DA Sinclair, K Mills, L Guarente
    posted to ageing by yedmonds on 2005-06-22 17:19:07 as ***
  • Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function.
    Ann N Y Acad Sci, Vol. 854 (20 November 1998), pp. 155-170.
    by YH Wei, CY Lu, HC Lee, CY Pang, YS Ma
    posted to ageing mitochondria oxidativestress by yedmonds on 2005-06-20 16:59:21 as ***
  • Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity.
    Exp Gerontol, Vol. 37, No. 10-11. (v 2002), pp. 1203-1205.
    by A Bürkle, S Beneke, C Brabeck, A Leake, R Meyer, ML Muiras, R Pfeiffer
    posted to ageing dnadamagerepair parp by yedmonds on 2005-06-20 19:59:26 as **
  • Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.
    Nature, Vol. 418, No. 6895. (18 July 2002), pp. 344-348.
    by SJ Lin, M Kaeberlein, AA Andalis, LA Sturtz, PA Defossez, VC Culotta, GR Fink, L Guarente
    posted to ageing cr sir2 by yedmonds on 2005-06-20 21:02:52 as *** along with 1 person lesander
  • Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span.
    Proc Natl Acad Sci U S A, Vol. 89, No. 24. (15 December 1992), pp. 11759-11763.
    by K Grube, A Bürkle
    posted to ageing parp by yedmonds on 2005-06-20 16:04:04 as *
  • Molecular links between aging and adipose tissue.
    Int J Obes Relat Metab Disord, Vol. 29 Suppl 1 (March 2005)
    by F Picard, L Guarente
    posted to adipocytes ageing sir2 by yedmonds on 2005-06-22 20:47:18 as read
  • Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
    J Biol Chem, Vol. 277, No. 47. (22 November 2002), pp. 45099-45107.
    by KJ Bitterman, RM Anderson, HY Cohen, M Latorre-Esteves, DA Sinclair
    posted to ageing nicotinamide silencing sir2 by yedmonds on 2005-06-20 21:03:50 as ***
  • Negative control of p53 by Sir2alpha promotes cell survival under stress.
    Cell, Vol. 107, No. 2. (19 October 2001), pp. 137-148.
    by J Luo, AY Nikolaev, S Imai, D Chen, F Su, A Shiloh, L Guarente, W Gu
    posted to ageing p53 sir2 by yedmonds on 2005-06-20 21:02:09 as ***
  • A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA.
    J Theor Biol, Vol. 213, No. 4. (21 December 2001), pp. 573-586.
    by PD Sozou, TB Kirkwood
    posted to ageing dnadamagerepair mitochondria oxidativestress telomeres by yedmonds on 2005-06-20 20:27:31 as **
  • Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.
    Nature, Vol. 423, No. 6936. (8 May 2003), pp. 181-185.
    by RM Anderson, KJ Bitterman, JG Wood, O Medvedik, DA Sinclair
    posted to ageing cr nicotinamide by yedmonds on 2005-06-20 21:26:19 as ** along with 2 people zhlei cito
  • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
    Nature, Vol. 425, No. 6954. (11 September 2003), pp. 191-196.
    by KT Howitz, KJ Bitterman, HY Cohen, DW Lamming, S Lavu, JG Wood, RE Zipkin, P Chung, A Kisielewski, LL Zhang, B Scherer, DA Sinclair
    posted to ageing resveratrol sir2 by yedmonds on 2005-06-22 13:49:19 as *** along with 1 person zhlei
  • Molecular gerontology. Bridging the simple and the complex.
    Ann N Y Acad Sci, Vol. 908 (June 2000), pp. 14-20.
    by TB Kirkwood
    posted to ageing by yedmonds on 2005-06-20 20:19:18 as *** along with 1 person jwc
  • p53 mutant mice that display early ageing-associated phenotypes.
    Nature, Vol. 415, No. 6867. (3 January 2002), pp. 45-53.
    by SD Tyner, S Venkatachalam, J Choi, S Jones, N Ghebranious, H Igelmann, X Lu, G Soron, B Cooper, C Brayton, S Hee Park, T Thompson, G Karsenty, A Bradley, LA Donehower
    posted to ageing p53 by yedmonds on 2005-06-20 21:04:29 as *
  • Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation.
    Cell Mol Life Sci, Vol. 58, No. 14. (December 2001), pp. 2108-2116.
    by K Matuoka, KY Chen, T Takenawa
    posted to ageing histones nicotinamide by yedmonds on 2005-06-22 14:32:17 as **
  • Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians.
    J Mol Med, Vol. 76, No. 5. (April 1998), pp. 346-354.
    by ML Muiras, M Müller, F Schächter, A Bürkle
    posted to ageing parp by yedmonds on 2005-06-20 16:52:32 as *
  • The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
    Proc Natl Acad Sci U S A, Vol. 97, No. 11. (23 May 2000), pp. 5807-5811.
    by J Landry, A Sutton, ST Tafrov, RC Heller, J Stebbins, L Pillus, R Sternglanz
    posted to ageing nadnadh sir2 by yedmonds on 2005-06-20 20:56:14 as **
  • Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?
    Diabetes, Vol. 51, No. 10. (October 2002), pp. 2951-2958.
    by I Gabriely, XH Ma, XM Yang, G Atzmon, MW Rajala, AH Berg, P Scherer, L Rossetti, N Barzilai
    posted to adipocytes adipokines ageing by yedmonds on 2005-06-22 20:52:13 as ** along with 1 person FW_Gibb
  • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
    Science, Vol. 289, No. 5487. (22 September 2000), pp. 2126-2128.
    by SJ Lin, PA Defossez, L Guarente
    posted to ageing cr nadnadh sir2 by yedmonds on 2005-06-20 20:52:14 as ** along with 1 person franklin
  • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.
    Nature, Vol. 403, No. 6771. (17 February 2000), pp. 795-800.
    by S Imai, CM Armstrong, M Kaeberlein, L Guarente
    posted to ageing histones sir2 by yedmonds on 2005-06-20 20:55:17 as *
  • Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
    Exp Cell Res, Vol. 220, No. 1. (September 1995), pp. 186-193.
    by T von Zglinicki, G Saretzki, W Döcke, C Lotze
    posted to ageing oxidativestress telomeres by yedmonds on 2005-06-20 20:29:42 as **
  • Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.
    J Biol Chem, Vol. 277, No. 21. (24 May 2002), pp. 18881-18890.
    by RM Anderson, KJ Bitterman, JG Wood, O Medvedik, H Cohen, SS Lin, JK Manchester, JI Gordon, DA Sinclair
    posted to ageing nadnadh by yedmonds on 2005-06-20 21:00:14 as ****
  • Poly(ADP-ribosyl)ation: a posttranslational protein modification linked with genome protection and mammalian longevity.
    Biogerontology, Vol. 1, No. 1. (2000), pp. 41-46.
    by A Bürkle
    posted to ageing genomicstability parp by yedmonds on 2005-06-20 17:01:59 as ****
  • Poly(ADP-ribosyl)ation, PARP, and aging.
    Sci Aging Knowledge Environ, Vol. 2004, No. 49. (8 December 2004)
    by S Beneke, A Bürkle
    posted to ageing par parp by yedmonds on 2005-06-20 16:58:17 as read
  • Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.
    Oncogene, Vol. 18, No. 37. (16 September 1999), pp. 5148-5158.
    by G Saretzki, N Sitte, U Merkel, RE Wurm, T von Zglinicki
    posted to ageing p53 telomeres by yedmonds on 2005-06-20 20:25:24 as **
  • PARP-1: a regulator of genomic stability linked with mammalian longevity.
    Chembiochem, Vol. 2, No. 10. (1 October 2001), pp. 725-728.
    by A Bürkle
    posted to ageing genomicstability parp by yedmonds on 2005-06-20 16:49:37 as read
  • Food, reproduction and longevity: is the extended lifespan of calorie-restricted animals an evolutionary adaptation?
    Bioessays, Vol. 10, No. 4. (April 1989), pp. 125-127.
    by R Holliday
    posted to ageing cr by yedmonds on 2005-06-22 20:51:13 as **
  • The role of fat cell derived peptides in age-related metabolic alterations.
    Mech Ageing Dev, Vol. 122, No. 14. (30 September 2001), pp. 1565-1576.
    by I Gabriely, N Barzilai
    posted to adipocytes adipokines ageing by yedmonds on 2005-06-22 20:54:20 as **
  • Extended longevity in mice lacking the insulin receptor in adipose tissue.
    Science, Vol. 299, No. 5606. (24 January 2003), pp. 572-574.
    by M Blüher, BB Kahn, CR Kahn
    posted to adipocytes ageing insulinreceptpr by yedmonds on 2005-06-22 20:49:34 as *** along with 1 group Fasting, food and evolution
  • A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process.
    Mutat Res, Vol. 316, No. 5-6. (May 1996), pp. 209-236.
    by A Kowald, TB Kirkwood
    posted to ageing mitochondria oxidativestress by yedmonds on 2005-06-20 20:16:33 as ***
  • Comparative characterisation of poly(ADP-ribose) polymerase-1 from two mammalian species with different life span.
    Exp Gerontol, Vol. 35, No. 8. (October 2000), pp. 989-1002.
    by S Beneke, R Alvarez-Gonzalez, A Bürkle
    posted to ageing parp by yedmonds on 2005-06-20 16:23:53 as *
  • The biology of aging.
    Mt Sinai J Med, Vol. 70, No. 1. (January 2003), pp. 3-22.
    by BR Troen
    posted to ageing by yedmonds on 2005-06-20 20:32:29 as read
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