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Ключевое слово agonist [48 articles]

Recent papers classified by the tag agonist.
  • Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein.
    Proc Natl Acad Sci U S A, Vol. 98, No. 15. (17 July 2001), pp. 8469-8474.
    by G Peleg, P Ghanouni, BK Kobilka, RN Zare
    posted to activation agonist b2ar by xdeupi on 2005-12-16 10:21:35 as read along with 1 person and 2 groups yanjiang LabCompMed moernerlab
  • Role of group-conserved residues in the helical core of beta2-adrenergic receptor.
    Proc Natl Acad Sci U S A, Vol. 104, No. 17. (24 April 2007), pp. 7027-7032.
    by P Chelikani, V Hornak, M Eilers, PJ Reeves, SO Smith, UL Rajbhandary, HG Khorana
    posted to activation agonist b2ar ser switch tm4 by xdeupi on 2007-04-26 12:27:17 as ** along with 1 group LabCompMed
  • Linking agonist binding to histamine H1 receptor activation
    Nat Chem Biol, Vol. 1, No. 2. (July 2005), pp. 98-103.
    by Aldo Jongejan, Martijn Bruysters, Juan A Ballesteros, Eric Haaksma, Remko A Bakker, Leonardo Pardo, Rob Leurs
    posted to activation agonist binding histamine n745 npxxy by xdeupi on 2005-11-01 01:19:58 as read along with 1 group LabCompMed
  • beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor.
    J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676.
    by MT Drake, JD Violin, EJ Whalen, JW Wisler, SK Shenoy, RJ Lefkowitz
    posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi on 2008-02-27 10:39:07 as *** along with 1 group LabCompMed
  • "Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology.
    Biochem Pharmacol, Vol. 73, No. 6. (15 March 2007), pp. 737-751.
    by CP Nelson, RA Challiss
    posted to agonist gpcr ligands pharmacology by xdeupi on 2007-04-10 18:54:26 as ** along with 1 person and 2 groups Fritz neurolit LabCompMed
  • Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV and -VI.
    Mol Pharmacol (14 December 2006)
    by Mette M M Rosenkilde, Michael B B Andersen, Rie Nygaard, Thomas M M Frimurer, Thue W W Schwartz
    posted to ligands ionic chemokine cation-pi agonist activation by xdeupi on 2007-01-11 16:06:35 as ** along with 1 group LabCompMed
  • Molecular mechanisms of beta2-adrenergic receptor function and regulation.
    Proc Am Thorac Soc, Vol. 2, No. 4. (2005)
    by DW McGraw, SB Liggett
    posted to activation agonist b2ar by xdeupi on 2006-02-20 09:27:39 as *** along with 1 group LabCompMed
  • Agonist binding: a multistep process.
    Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1060-1062.
    by B Kobilka
    posted to activation agonist b2ar binding gpcr by xdeupi on 2005-11-02 22:50:37 as ** along with 1 group LabCompMed
  • Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists.
    J Pharmacol Exp Ther (20 July 2006)
    by Terry P P Kenakin, Stephen Jenkinson, Christian Watson
    posted to activation drug ligands agonist pharmacology by xdeupi on 2006-09-05 09:51:58 as **** along with 1 group LabCompMed
  • Subclassification and nomenclature of alpha- and beta-adrenoceptors.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 129-134.
    by JP Hieble
    posted to agonist b2ar drug genome ligands pharmacology review by xdeupi on 2007-03-12 14:33:19 as ** along with 1 group LabCompMed
  • Catechol-binding serines of beta(2)-adrenergic receptors control the equilibrium between active and inactive receptor states.
    Mol Pharmacol, Vol. 57, No. 1. (January 2000), pp. 198-210.
    by C Ambrosio, P Molinari, S Cotecchia, T Costa
    posted to activation agonist b2ar ser tm5 by xdeupi on 2005-10-31 23:56:50 as read along with 1 group LabCompMed
  • Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptor.
    Br J Pharmacol, Vol. 135, No. 7. (April 2002), pp. 1715-1722.
    by R Del Carmine, C Ambrosio, M Sbraccia, S Cotecchia, AP Ijzerman, T Costa
    posted to activation agonist b2ar by xdeupi on 2005-10-31 23:55:27 as **** along with 1 group LabCompMed
  • Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.
    J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125.
    by B Behr, C Hoffmann, G Ottolina, KN Klotz
    posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as *** along with 1 group LabCompMed
  • Chemogenomic approaches to rational drug design
    Br J Pharmacol, Vol. 152, No. 1. (29 May 2007), pp. 38-52.
    by D Rognan
    posted to agonist binding drug ligands pharmacology priviledged_structures by xdeupi on 2008-03-28 15:54:47 as ** along with 4 people and 3 groups jmrivort jerome_ucsf_slb jyuh tjimenez LabCompMed G-quadruplex Supramolecular
  • Recruitment of beta-arrestin2 to the dopamine D2 receptor: Insights into anti-psychotic and anti-parkinsonian drug receptor signaling.
    Neuropharmacology (8 April 2008)
    by Ib V V Klewe, Søren M M Nielsen, Louise Tarpø, Eneko Urizar, Concetta Dipace, Jonathan A A Javitch, Ulrik Gether, Jan Egebjerg, Kenneth V V Christensen
    posted to activation active-state agonist arrestin biased_agonism binding disease fluorescence imaging internalization pharmacology by xdeupi on 2008-05-13 16:24:49 as **
  • Chromophore Channeling in the G-Protein Coupled Receptor Rhodopsin.
    J Am Chem Soc (15 May 2007)
    by Ting Wang, Yong Duan
    posted to activation agonist amber binding ligands md modeling rhodopsin by xdeupi on 2007-05-21 10:04:04 as ***** along with 1 group LabCompMed
  • Bioluminescence resonance energy transfer as a screening assay: Focus on partial and inverse agonism.
    J Biomol Screen, Vol. 12, No. 1. (February 2007), pp. 41-49.
    by L Elster, C Elling, A Heding
    posted to activation agonist b2ar fret ligands by xdeupi on 2007-04-10 18:50:15 as ** along with 1 group LabCompMed
  • Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.
    Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1181-1190.
    by G Liapakis, WC Chan, M Papadokostaki, JA Javitch
    posted to activation agonist b2ar by xdeupi on 2005-11-01 00:57:14 as read along with 1 group LabCompMed
  • Multiple signaling states of G-protein-coupled receptors.
    Pharmacol Rev, Vol. 57, No. 2. (June 2005), pp. 147-161.
    by DM Perez, SS Karnik
    posted to activation agonist gpcr pharmacology review rhodopsin switch by xdeupi on 2007-04-26 14:57:25 as ***** along with 1 group LabCompMed
  • Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists.
    J Biol Chem, Vol. 280, No. 23. (10 June 2005), pp. 22165-22171.
    by G Swaminath, X Deupi, TW Lee, W Zhu, FS Thian, TS Kobilka, B Kobilka
    posted to activation agonist b2ar switch toggle by xdeupi on 2005-10-25 01:25:28 as read along with 1 person and 3 groups marcius BioinfoCIPF LabCompMed SGU-CIPF
  • Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein-Coupled Receptor Signaling.
    PLoS Comput Biol, Vol. 3, No. 1. (12 January 2007)
    by Tamara L L Kinzer-Ursem, Jennifer J J Linderman
    posted to activation agonist b2ar pharmacology by xdeupi on 2007-02-13 15:38:17 as **** along with 1 group LabCompMed
  • Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor.
    J Biol Chem, Vol. 276, No. 27. (6 July 2001), pp. 24433-24436.
    by P Ghanouni, Z Gryczynski, JJ Steenhuis, TW Lee, DL Farrens, JR Lakowicz, BK Kobilka
    posted to activation agonist b2ar by xdeupi on 2005-12-16 10:23:33 as read along with 1 group LabCompMed
  • GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors.
    Curr Top Med Chem, Vol. 6, No. 13. (2006), pp. 1319-1333.
    by MM Rosenkilde, TW Schwartz
    posted to modeling ligands ionic chemokine binding agonist by xdeupi on 2007-01-10 14:45:13 as ** along with 1 group LabCompMed
  • Principal pathway coupling agonist binding to channel gating in nicotinic receptors
    Nature, Vol. 438, No. 7065. (10 November 2005), pp. 243-247.
    by Won Y Lee, Steven M Sine
    posted to activation agonist binding channel ser by xdeupi on 2006-01-27 12:32:01 as ** along with 1 person and 3 groups barry structural_bioinformatics Bioinformatics LabCompMed
  • notes The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.
    J Biol Chem, Vol. 275, No. 48. (1 December 2000), pp. 37779-37788.
    by G Liapakis, JA Ballesteros, S Papachristou, WC Chan, X Chen, JA Javitch
    posted to activation agonist b2ar binding s542 ser tm5 by xdeupi on 2005-11-01 01:02:07 as ** along with 1 group LabCompMed
  • Partial Agonism in a G Protein-coupled Receptor: ROLE OF THE RETINAL RING STRUCTURE IN RHODOPSIN ACTIVATION
    J. Biol. Chem., Vol. 280, No. 40. (7 October 2005), pp. 34259-34267.
    by Franz J Bartl, Olaf Fritze, Eglof Ritter, Rolf Herrmann, Vladimir Kuksa, Krzysztof Palczewski, Klaus P Hofmann, Oliver P Ernst
    posted to activation agonist rhodopsin by xdeupi on 2005-11-22 19:52:14 as *** along with 1 group LabCompMed
  • Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor.
    J Biol Chem, Vol. 280, No. 41. (14 October 2005), pp. 34849-34858.
    by SJ Han, FF Hamdan, SK Kim, KA Jacobson, LM Bloodworth, B Li, J Wess
    posted to ligands cation-pi binding agonist by xdeupi on 2007-01-15 16:08:15 as ** along with 1 group LabCompMed
  • Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 207-216.
    by JP Hieble
    posted to agonist b2ar drug ligands pharmacology by xdeupi on 2007-03-12 14:32:04 as ** along with 1 group LabCompMed
  • Data-Driven Analysis in Drug Discovery
    Journal of Receptors and Signal Transduction, Vol. 26, No. 4. (August 2006), pp. 299-327.
    by Terry Kenakin
    posted to agonist binding drug ligands pharmacology by xdeupi on 2006-07-17 16:28:05 as **** along with 1 group LabCompMed
  • The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop.
    Annu Rev Pharmacol Toxicol, Vol. 42 (2002), pp. 437-467.
    by L Shi, JA Javitch
    posted to agonist binding ecl2 gpcr helix loops transmembrane by xdeupi on 2005-11-01 01:00:19 as ** along with 1 person and 1 group IrinaMoreira LabCompMed
  • Different structural requirements for the constitutive and the agonist-induced activities of the beta2-adrenergic receptor.
    J Biol Chem, Vol. 280, No. 25. (24 June 2005), pp. 23464-23474.
    by C Ambrosio, P Molinari, F Fanelli, Y Chuman, M Sbraccia, O Ugur, T Costa
    posted to activation agonist b2ar ser by xdeupi on 2005-10-31 23:54:01 as ***** along with 1 group LabCompMed
  • Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states.
    J Biol Chem, Vol. 279, No. 1. (2 January 2004), pp. 686-691.
    by G Swaminath, Y Xiang, TW Lee, J Steenhuis, C Parnot, BK Kobilka
    posted to activation agonist b2ar binding ligands tm6 by xdeupi on 2005-12-16 10:19:18 as read along with 1 person and 1 group jddowney LabCompMed
  • notes Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol.
    J Clin Invest, Vol. 117, No. 1. (January 2007), pp. 229-235.
    by F Rochais, JP Vilardaga, VO Nikolaev, M Bünemann, MJ Lohse, S Engelhardt
    posted to activation agonist b2ar helix8 mutation by xdeupi on 2007-03-12 14:39:00 as ***** along with 1 group LabCompMed
  • Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor.
    Proc Natl Acad Sci U S A, Vol. 98, No. 11. (22 May 2001), pp. 5997-6002.
    by P Ghanouni, JJ Steenhuis, DL Farrens, BK Kobilka
    posted to activation agonist b2ar fluorescence by xdeupi on 2005-12-16 10:22:41 as ** along with 1 group LabCompMed
  • "Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor.
    Mol Pharmacol, Vol. 66, No. 2. (August 2004), pp. 356-363.
    by R Del Carmine, P Molinari, M Sbraccia, C Ambrosio, T Costa
    posted to activation agonist b2ar by xdeupi on 2005-10-31 23:54:36 as ** along with 1 group LabCompMed
  • Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines.
    J Med Chem, Vol. 49, No. 5. (9 March 2006), pp. 1706-1719.
    by H Xhaard, VV Rantanen, T Nyrönen, MS Johnson
    posted to agonist b2ar binding gpcr ligands modeling by xdeupi on 2006-03-06 10:11:30 as **** along with 1 group LabCompMed
  • GPCR agonists and antagonists in the clinic.
    Med Chem, Vol. 1, No. 4. (July 2005), pp. 405-421.
    by JD Tyndall, R Sandilya
    posted to agonist drug gpcr ligands pharmacology by xdeupi on 2006-07-24 10:18:01 as ** along with 1 group LabCompMed
  • New concepts in drug discovery: collateral efficacy and permissive antagonism.
    Nat Rev Drug Discov, Vol. 4, No. 11. (November 2005), pp. 919-927.
    by T Kenakin
    posted to activation agonist ccr5 gpcr ligands by xdeupi on 2005-11-04 21:57:24 as ** along with 1 group LabCompMed
  • Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists.
    Front Biosci, Vol. 13 (2008), pp. 1813-1826.
    by R Kapadia, JH Yi, R Vemuganti
    posted to agonist antiinflammatorisch future ppar-gamma by viki on 2007-11-24 09:01:30 as **
  • Allosteric Activation of the Follicle-stimulating Hormone (FSH) Receptor by Selective, Nonpeptide Agonists
    J. Biol. Chem., Vol. 281, No. 19. (12 May 2006), pp. 13226-13233.
    by Stephen D Yanofsky, Emily S Shen, Frank Holden, Erik Whitehorn, Barbara Aguilar, Emily Tate, Christopher P Holmes, Randall Scheuerman, Derek Maclean, May M Wu, Donald E Frail, Francisco J Lopez, Richard Winneker, Brian J Arey, Ronald W Barrett
    posted to agonist fsh by ndoelker on 2006-11-07 14:52:10 as ***** along with 1 group LabCompMed
  • Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    Diabetes, Vol. 48, No. 5. (1 May 1999), pp. 1026-1034.
    by Aa Young, Br Gedulin, S Bhavsar, N Bodkin, C Jodka, B Hansen, M Denaro
    posted to 1 agonist biosci353 diabetes exenatide exendin-4 glp-1r glucagon like peptide by cherrie to the group CAOS on 2006-08-04 03:49:13 as **
  • Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    J Med Chem, Vol. 47, No. 26. (16 December 2004), pp. 6616-6624.
    by M Leopoldo, F Berardi, NA Colabufo, M Contino, E Lacivita, M Niso, R Perrone, V Tortorella
    posted to 5-ht7 agonist lp44 by dark_innocent to the group neurolit on 2006-10-30 15:36:34 as ** along with 1 person Fritz
  • Molecular basis of inverse agonism in a G protein-coupled receptor.
    Nat Chem Biol, Vol. 1, No. 1. (June 2005), pp. 25-28.
    by JP Vilardaga, R Steinmeyer, GS Harms, MJ Lohse
    posted to agonist g-protein gpcr by Fritz to the group neurolit on 2006-07-07 22:12:21 as ** along with 1 person awooga
  • Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task.
    Behav Brain Res, Vol. 163, No. 1. (30 August 2005), pp. 136-140.
    by GS Perez-García, A Meneses
    posted to 5-ht-receptors 5-ht7 agonist as19 by dark_innocent to the group neurolit on 2007-02-14 13:30:09 as ** along with 1 person Fritz
  • [3H]Org 43553, the First Low Molecular Weight Agonistic and Allosteric Radioligand for the Human Luteinizing Hormone Receptor.
    Mol Pharmacol (7 November 2007)
    by Laura Heitman, Julia Oosterom, Kimberly Bonger, Cornelis Timmers, Peter Wiegerinck, Ad P P Ijzerman
    posted to agonist hcg lhr lmw lowmolecularweigth by gcaltabiano on 2007-11-13 08:41:31 as **
  • Effects of CP-336,156, a New, Nonsteroidal Estrogen Agonist/Antagonist, on Bone, Serum Cholesterol, Uterus, and Body Composition in Rat Models
    Endocrinology, Vol. 139, No. 4. (1 April 1998), pp. 2068-2076.
    by Hua Z Ke, Vishwas M Paralkar, William A Grasser, Todd D Crawford, Hong Qi, Hollis A Simmons, Christine M Pirie, Kristin L Chidsey-Frink, Thomas A Owen, Steven L Smock, Hong K Chen, Webster S Jee, Kimberly O Cameron, Robert L Rosati, Thomas A Brown, Paul Dasilva-Jardine, David D Thompson
    posted to agonist antagonist body distribution estrogen fat rat by FW_Gibb on 2007-05-23 13:54:50 as **
  • Choline is transported by vesicular acetylcholine transporter.
    J Neurochem, Vol. 91, No. 3. (November 2004), pp. 766-768.
    by DT Bravo, NG Kolmakova, SM Parsons
    posted to agonist choline receptor vacht by chenlc03 on 2006-10-11 12:26:31 as **
  • Movement of ‘gating charge’ is coupled to ligand binding in a G-protein-coupled receptor
    Nature (25 October 2006)
    by Yair Ben-Chaim, Baron Chanda, Nathan Dascal, Francisco Bezanilla, Itzchak Parnas, Hanna Parnas
    posted to activation agonist gpcr by cen4ik on 2006-11-02 13:03:34 as ***
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