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Ключевое слово drug [421 articles]

Recent papers classified by the tag drug.
  • Targeting cancer: the challenges and successes of structure-based drug design against the human purinome
    Current Topics In Medicinal Chemistry, Vol. 6, No. 11. (2006), pp. 1129-1159.
    by Mark Knapp, Cornelia Bellamacina, Jeremy M Murray, Dirksen E Bussiere
    posted to drug by yiban on 2006-08-01 15:19:29 as ** along with 1 person and 2 groups barry structural_bioinformatics Bioinformatics
  • Implications of protein flexibility for drug discovery.
    Nat Rev Drug Discov, Vol. 2, No. 7. (July 2003), pp. 527-541.
    by SJ Teague
    posted to discovery drug by yiban on 2006-08-01 14:41:40 as *** along with 5 people higueruelo aqeel simone kazemi LamBras
  • Targeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins
    PLoS Medicine, Vol. 3, No. 11. (1 November 2006), e427.
    by Ekaterina Dadachova, Mahesh C Patel, Sima Toussi, Christos Apostolidis, Alfred Morgenstern, Martin W Brechbiel, Miroslaw K Gorny, Susan Zolla-Pazner, Arturo Casadevall, Harris Goldstein
    posted to antibody discovery drug mab by yeastyboy on 2006-11-19 09:38:44 as **
  • High-dimensional and large-scale phenotyping of yeast mutants
    PNAS, Vol. 102, No. 52. (27 December 2005), pp. 19015-19020.
    by Yoshikazu Ohya, Jun Sese, Masashi Yukawa, Fumi Sano, Yoichiro Nakatani, Taro L Saito, Ayaka Saka, Tomoyuki Fukuda, Satoru Ishihara, Satomi Oka, Genjiro Suzuki, Machika Watanabe, Aiko Hirata, Miwaka Ohtani, Hiroshi Sawai, Nicolas Fraysse, Jean-Paul Latge, Jean M Francois, Markus Aebi, Seiji Tanaka, Sachiko Muramatsu, Hiroyuki Araki, Kintake Sonoike, Satoru Nogami, Shinichi Morishita
    posted to discovery drug in vivo yeast by yeastyboy on 2006-12-22 10:03:02 as ***** along with 3 people sesejun cjeans jiny
  • Structure-based maximal affinity model predicts small-molecule druggability
    Nature Biotechnology, Vol. 25, No. 1. (08 January 2007), pp. 71-75.
    by Alan C Cheng, Ryan G Coleman, Kathleen T Smyth, Qing Cao, Patricia Soulard, Daniel R Caffrey, Anna C Salzberg, Enoch S Huang
    posted to discovery drug molecule small by yeastyboy on 2007-09-11 12:37:42 as ** along with 3 people higueruelo jerome willpitt
  • ErbB receptors: new insights on mechanisms and biology
    Trends in Cell Biology, Vol. 16, No. 12. (December 2006), pp. 649-656.
    by Bryan Linggi, Graham Carpenter
    posted to cancer drug erbb-receptors by yeastyboy on 2006-11-30 08:23:22 as ** along with 1 person jyuh
  • Genomics and proteomics tools for compound mode-of-action studies in drug discovery.
    Pharmacogenomics, Vol. 5, No. 4. (June 2004), pp. 395-404.
    by N Kley, I Ivanov, S Meier-Ewert
    posted to yeast two-hybrid protein interaction drug by yeastyboy on 2007-02-11 11:45:50 as *****
  • Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting
    Nature Biotechnology, Vol. 25, No. 8. (05 August 2007), pp. 921-929.
    by Xiao-Qing Qiu, He Wang, Bei Cai, Lan-Lan Wang, Shi-Tao Yue
    posted to antibody discovery display drug by yeastyboy on 2007-08-14 09:14:02 as *** along with 1 person pattisyang
  • Interrogating yeast surface displayed human proteome to identify small molecule binding proteins.
    Mol Cell Proteomics (28 July 2007)
    by Scott Bidlingmaier, Bin Liu
    posted to discovery display drug molecule small yeast by yeastyboy on 2007-08-07 16:27:19 as ***
  • Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.
    Proc Natl Acad Sci U S A, Vol. 103, No. 6. (7 February 2006), pp. 1888-1893.
    by C Tovar, J Rosinski, Z Filipovic, B Higgins, K Kolinsky, H Hilton, X Zhao, BT Vu, W Qing, K Packman, O Myklebost, DC Heimbrook, LT Vassilev
    posted to discovery drug interaction molecule nutlin p53 protein small by yeastyboy on 2007-09-16 14:08:35 as read along with 2 people Evangelia sbiring
  • PTK787/ZK 222584, a Specific Vascular Endothelial Growth Factor-Receptor Tyrosine Kinase Inhibitor, Affects the Anatomy of the Tumor Vascular Bed and the Functional Vascular Properties as Detected by Dynamic Enhanced Magnetic Resonance Imaging
    Cancer Res, Vol. 62, No. 14. (15 July 2002), pp. 4015-4022.
    by Joachim Drevs, Ralph Muller-Driver, Christine Wittig, Stefan Fuxius, Norbert Esser, Harald Hugenschmidt, Moritz A Konerding, Peter R Allegrini, Jeanette Wood, Jurgen Hennig, Clemens Unger, Dieter Marme
    posted to angiogenesis dce-mri drug by xtizon on 2007-08-02 09:56:28 as *****
  • Drug Insight: VEGF as a therapeutic target for breast cancer
    Nat Clin Prac Oncol, Vol. 4, No. 3. (March 2007), pp. 181-189.
    by Bryan P Schneider, George W Sledge
    posted to breast cancer drug review vegf by xtizon on 2007-04-25 08:44:58 as **** along with 1 person ishak
  • Validating cancer drug targets
    Nature, Vol. 441, No. 7092. (24 May 2006), pp. 451-456.
    by John D Benson, Ying-Nan P Chen, Susan A Cornell-Kennon, Marion Dorsch, Sunkyu Kim, Magdalena Leszczyniecka, William R Sellers, Christoph Lengauer
    posted to cancer drug by xtizon on 2007-03-02 14:39:48 as ***** along with 1 person and 1 group karthikram Neoscientists
  • A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding.
    Drug Discov Today, Vol. 12, No. 15-16. (August 2007), pp. 622-633.
    by Marie A A Bogoyevitch, David P P Fairlie
    posted to cancer drug pharmacology by xtizon on 2008-02-17 19:49:02 as ** along with 2 people higueruelo bicko
  • Is there a common molecular pathway for addiction?
    Nature Neuroscience, Vol. 8, No. 11. (26 October 2005), pp. 1445-1449.
    by Eric J Nestler
    posted to addiction common dopamine drug mechanism moleculer pathway by xico on 2006-03-25 21:21:59 as **** along with 1 person and 1 group psique WetBiology
  • Neural mechanisms of addiction: the role of reward-related learning and memory.
    Annu Rev Neurosci, Vol. 29 (2006), pp. 565-598.
    by SE Hyman, RC Malenka, EJ Nestler
    posted to reward review opiates memory mechanism learning drug brain addiction by xico on 2007-02-02 19:54:45 as *** along with 3 people and 1 group nishiokov mattions makikasahara WetBiology
  • Involvement of the endocannabinoid system in drug addiction
    Trends in Neurosciences, Vol. 29, No. 4. (April 2006), pp. 225-232.
    by Rafael Maldonado, Olga Valverde, Fernando Berrendero
    posted to endocannabinoid drug cannabis add by xico on 2008-06-25 08:02:59 as **
  • notes The evolutionary origins and significance of drug addiction
    Harm Reduction Journal, Vol. 2, No. 1. (2005)
    by Tammy Saah
    posted to addiction darwinism drug evolution fitness plant psychotropic by xico on 2007-06-26 22:36:17 as read along with 1 group WetBiology
  • THE ENDOCANNABINOID SYSTEM AND ITS THERAPEUTIC EXPLOITATION
    Nat Rev Drug Discov, Vol. 3, No. 9. (2004), pp. 771-784.
    by Vincenzo D Marzo, Maurizio Bifulco, Luciano D Petrocellis
    posted to anandamide dag design drug endocannabinoid system thc therapeutic by xico on 2006-09-24 19:43:24 as **** along with 2 people and 1 group Yanno zobag WetBiology
  • Marijuana and cannabinoid regulation of brain reward circuits
    British Journal Of Pharmacology, Vol. 143, No. 2. (2004), pp. 227-234.
    by Carl R Lupica, Arthur C Riegel, Alexander F Hoffman
    posted to abuse addiction brain cannabinoid drug marijuana mechanism neuro-adaptation neuromediator plasticity review reward by xico on 2005-12-23 22:47:09 as **** along with 1 group WetBiology
  • notes History of cannabis as a medicine: a review.
    Rev Bras Psiquiatr, Vol. 28, No. 2. (June 2006), pp. 153-157.
    by AW Zuardi
    posted to cannabis drug history medecine medical review sativa by xico on 2007-07-01 22:49:54 as read along with 1 group WetBiology
  • Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, No. 4. (24 January 2007), pp. 791-795.
    by JF Cheer, KM Wassum, LA Sombers, ML Heien, JL Ariansen, BJ Aragona, PE Phillips, RM Wightman
    posted to rimonabant recreational receptor nucleus na drug dopamine cocaine cb1 cannabis cannabinoid antagonist accumbens abuse by xico on 2008-05-15 01:02:26 as **
  • The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies.
    Neuropharmacology, Vol. 47 Suppl 1 (2004), pp. 3-13.
    by ND Volkow, JS Fowler, GJ Wang
    posted to addiction drug mri ddicted imaging pet treatment brain circuit damage neuroimaging review by xico on 2007-06-05 20:53:45 as ** along with 1 group WetBiology
  • Mood stabilizers, glycogen synthase kinase-3beta and cell survival.
    Mol Psychiatry, Vol. 7 Suppl 1 (2002)
    by RS Jope, GN Bijur
    posted to anti-depressant bipolar depression disorder drug glycogen gsk-3-beta kinase-3-beta lithium mania mood psychiatry psychosis stabilizer synthase by xico on 2007-07-06 17:22:20 as ** along with 1 group WetBiology
  • Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
    The EMBO Journal, Vol. aop, No. current. (14 December 2006)
    by Yutong Sun, Jianyun Huang, Yang Xiang, Murat Bastepe, Harald Juppner, Brian K Kobilka, Jillian J Zhang, Xin-Yun Huang
    posted to activation b2ar drug pharmacology switch by xdeupi on 2007-03-21 11:13:23 as ** along with 1 person and 1 group Guff32 LabCompMed
  • Clinical consequences of ADR2 polymorphisms
    Pharmacogenomics, Vol. 9, No. 3. (March 2008), pp. 349-358.
    by Hawkins, A Gregory, Weiss, T Scott, Bleecker, R Eugene
    posted to review polymorphism pharmacology genome drug disease b2ar by xdeupi on 2008-05-03 17:12:39 as **
  • Functional assays as prismatic views of drug activity: relevance to new drug discovery.
    Journal of receptor and signal transduction research, Vol. 28, No. 1. (2008), pp. 109-125.
    by T Kenakin
    posted to review pharmacology drug chemokine biased_agonism by xdeupi on 2008-05-03 17:03:08 as **
  • Smart drug discovery leveraging innovative technologies and predictive knowledge.
    Nat Chem Biol, Vol. 2, No. 12. (December 2006), pp. 646-648.
    by TK Sawyer
    posted to drug pharmacology by xdeupi on 2007-04-23 16:56:56 as ** along with 1 group LabCompMed
  • Chemical Biology & Drug Design: First Anniversary - 2007!
    Chem Biol Drug Des, Vol. 69, No. 1. (January 2007), pp. 1-2.
    by Tomi K K Sawyer
    posted to drug pharmacology review by xdeupi on 2007-04-23 16:56:17 as ** along with 1 group LabCompMed
  • Chemogenomic approaches to rational drug design
    Br J Pharmacol, Vol. 152, No. 1. (29 May 2007), pp. 38-52.
    by D Rognan
    posted to agonist binding drug ligands pharmacology priviledged_structures by xdeupi on 2008-03-28 15:54:47 as ** along with 3 people and 3 groups jyuh jmrivort jerome_ucsf_slb LabCompMed G-quadruplex Supramolecular
  • Subclassification and nomenclature of alpha- and beta-adrenoceptors.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 129-134.
    by JP Hieble
    posted to agonist b2ar drug genome ligands pharmacology review by xdeupi on 2007-03-12 14:33:19 as ** along with 1 group LabCompMed
  • Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 207-216.
    by JP Hieble
    posted to agonist b2ar drug ligands pharmacology by xdeupi on 2007-03-12 14:32:04 as ** along with 1 group LabCompMed
  • Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor.
    J Comput Aided Mol Des (13 October 2006)
    by Stanley R Krystek, S R Kimura, Andrew J Tebben
    posted to b2ar binding drug ligands modeling pharmacology by xdeupi on 2006-10-27 09:43:03 as ** along with 1 person and 1 group daevans LabCompMed
  • Data-Driven Analysis in Drug Discovery
    Journal of Receptors and Signal Transduction, Vol. 26, No. 4. (August 2006), pp. 299-327.
    by Terry Kenakin
    posted to agonist binding drug ligands pharmacology by xdeupi on 2006-07-17 16:28:05 as **** along with 1 group LabCompMed
  • The identification of ligands at orphan G-protein coupled receptors.
    Annu Rev Pharmacol Toxicol, Vol. 44 (2004), pp. 43-66.
    by A Wise, SC Jupe, S Rees
    posted to drug gpcr ligands by xdeupi on 2006-03-01 16:35:26 as ** along with 1 group LabCompMed
  • notes Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor.
    J Biol Chem, Vol. 274, No. 31. (30 July 1999), pp. 21867-21872.
    by A Marjamäki, H Frang, M Pihlavisto, AM Hoffrén, T Salminen, MS Johnson, J Kallio, JA Javitch, M Scheinin
    posted to activation binding cys_scanning drug ligands tm5 by xdeupi on 2008-03-07 15:14:37 as ** along with 1 group LabCompMed
  • Latest development in drug discovery on G protein-coupled receptors.
    Curr Protein Pept Sci, Vol. 7, No. 5. (October 2006), pp. 465-470.
    by K Lundstrom
    posted to drug gpcr review by xdeupi on 2006-11-04 12:42:42 as ** along with 1 person and 1 group denissohy LabCompMed
  • I want a new drug: G-protein-coupled receptors in drug development.
    Drug Discov Today, Vol. 11, No. 11-12. (June 2006), pp. 481-493.
    by S Schlyer, R Horuk
    posted to drug gpcr ligands pharmacology review by xdeupi on 2006-11-04 12:41:53 as ** along with 1 group LabCompMed
  • GPCR agonists and antagonists in the clinic.
    Med Chem, Vol. 1, No. 4. (July 2005), pp. 405-421.
    by JD Tyndall, R Sandilya
    posted to agonist drug gpcr ligands pharmacology by xdeupi on 2006-07-24 10:18:01 as ** along with 1 group LabCompMed
  • GPCR antitarget modeling: pharmacophore models for biogenic amine binding GPCRs to avoid GPCR-mediated side effects.
    Chembiochem, Vol. 6, No. 5. (May 2005), pp. 876-889.
    by T Klabunde, A Evers
    posted to amine drug by xdeupi on 2006-01-11 11:25:41 as ** along with 1 group LabCompMed
  • GLIDA: GPCR-ligand database for chemical genomic drug discovery.
    Nucleic Acids Res, Vol. 34, No. Database issue. (1 January 2006)
    by Y Okuno, J Yang, K Taneishi, H Yabuuchi, G Tsujimoto
    posted to drug by xdeupi on 2006-01-11 11:22:31 as ** along with 1 person and 1 group kuhn LabCompMed
  • A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.
    Proc Natl Acad Sci U S A, Vol. 103, No. 30. (25 July 2006), pp. 11288-11293.
    by SB Liggett, J Mialet-Perez, S Thaneemit-Chen, SA Weber, SM Greene, D Hodne, B Nelson, J Morrison, MJ Domanski, LE Wagoner, WT Abraham, JL Anderson, JF Carlquist, HJ Krause-Steinrauf, LC Lazzeroni, JD Port, PW Lavori, MR Bristow
    posted to b2ar disease drug genome helix8 ligands polymorphism by xdeupi on 2006-09-05 11:38:25 as ** along with 1 group LabCompMed
  • Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.
    J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125.
    by B Behr, C Hoffmann, G Ottolina, KN Klotz
    posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as *** along with 1 group LabCompMed
  • G proteins in drug screening: from analysis of receptor-G protein specificity to manipulation of GPCR-mediated signalling pathways.
    Curr Pharm Des, Vol. 12, No. 14. (2006), pp. 1703-1715.
    by E Kostenis
    posted to activation cterm drug ecl2 gpcr gproteins pharmacology by xdeupi on 2006-09-05 09:59:05 as **** along with 1 group LabCompMed
  • Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists.
    J Pharmacol Exp Ther (20 July 2006)
    by Terry P P Kenakin, Stephen Jenkinson, Christian Watson
    posted to activation drug ligands agonist pharmacology by xdeupi on 2006-09-05 09:51:58 as **** along with 1 group LabCompMed
  • beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor.
    J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676.
    by MT Drake, JD Violin, EJ Whalen, JW Wisler, SK Shenoy, RJ Lefkowitz
    posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi on 2008-02-27 10:39:07 as *** along with 1 group LabCompMed
  • Drugs, their targets and the nature and number of drug targets
    Nature Reviews Drug Discovery, Vol. 5, No. 10., pp. 821-834.
    by Peter Imming, Christian Sinning, Achim Meyer
    posted to review ligands gpcr genome drug by xdeupi on 2007-01-22 17:55:08 as ** along with 3 people and 1 group kuhn massivemayhem Ao_Li2007 LabCompMed
  • notes Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes
    Journal of Controlled Release, Vol. 63, No. 1-2. (3 January 2000), pp. 19-30.
    by Paola Crosasso, Maurizio Ceruti, Paola Brusa, Silvia Arpicco, Franco Dosio, Luigi Cattel
    posted to drug insol methods by wmanyi on 2006-12-21 07:46:16 as read
  • Drug-phospholipid interactions. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients
    Journal of Pharmaceutical Sciences, Vol. 86, No. 9. (1997), pp. 1034-1039.
    by Patrick Barton, Andrew M Davis, Dennis J Mccarthy, Peter JH Webborn
    posted to drug membrane by viktor21614 on 2007-08-01 14:16:03 as **
  • Benzodiazepine localisation at the lipid-water interface: effect of membrane composition and drug chemical structure
    Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1418, No. 1. (14 April 1999), pp. 221-231.
    by Daniel A Garcia, Maria A Perillo
    posted to drug membrane by viktor21614 on 2007-08-01 14:11:10 as **
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