Thymic Selection Determines [gamma][delta] T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon [gamma]

@article{citeulike:3043338, abstract = {Summary [gamma][delta] T cells uniquely contribute to host immune defense, but how this is accomplished remains unclear. Here, we analyzed the nonclassical major histocompatibility complex class I T10 and T22-specific [gamma][delta] T cells in mice and found that encountering antigen in the thymus was neither required nor inhibitory for their development. But when triggered through the T cell receptor, ligand-naive lymphoid-[gamma][delta] T cells produced IL-17, whereas ligand-experienced cells made IFN-[gamma]. Immediately after immunization, a large fraction of IL-17+ [gamma][delta] T cells were found in the draining lymph nodes days before the appearance of antigen-specific IL-17+ [alpha][beta] T cells. Thus, thymic selection determines the effector fate of [gamma][delta] T cells rather than constrains their antigen specificities. The swift IL-17 response mounted by antigen-naive [gamma][delta] T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens.}, author = {Jensen, Kirk D. and Su, Xiaoqin and Shin, Sunny and Li, Luke and Youssef, Sawsan and Yamasaki, Sho and Steinman, Lawrence and Saito, Takashi and Locksley, Richard M. and Davis, Mark M. and Baumgarth, Nicole and Chien, Yueh-Hsiu }, citeulike-article-id = {3043338}, doi = {http://dx.doi.org/10.1016/j.immuni.2008.04.022}, journal = {Immunity}, keywords = {il-17, th17}, month = {July}, number = {1}, pages = {90--100}, posted-at = {2008-07-25 18:49:12}, priority = {2}, title = {Thymic Selection Determines [gamma][delta] T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon [gamma]}, url = {http://dx.doi.org/10.1016/j.immuni.2008.04.022}, volume = {29}, year = {2008} }

TY - JOUR ID - citeulike:3043338 L3 - citeulike-article-id:3043338 TI - Thymic Selection Determines [gamma][delta] T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon [gamma] JF - Immunity VL - 29 IS - 1 SP - 90 EP - 100 N2 - Summary [gamma][delta] T cells uniquely contribute to host immune defense, but how this is accomplished remains unclear. Here, we analyzed the nonclassical major histocompatibility complex class I T10 and T22-specific [gamma][delta] T cells in mice and found that encountering antigen in the thymus was neither required nor inhibitory for their development. But when triggered through the T cell receptor, ligand-naive lymphoid-[gamma][delta] T cells produced IL-17, whereas ligand-experienced cells made IFN-[gamma]. Immediately after immunization, a large fraction of IL-17+ [gamma][delta] T cells were found in the draining lymph nodes days before the appearance of antigen-specific IL-17+ [alpha][beta] T cells. Thus, thymic selection determines the effector fate of [gamma][delta] T cells rather than constrains their antigen specificities. The swift IL-17 response mounted by antigen-naive [gamma][delta] T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens. KW - il-17 KW - th17 AU - Jensen, Kirk AU - Su, Xiaoqin AU - Shin, Sunny AU - Li, Luke AU - Youssef, Sawsan AU - Yamasaki, Sho AU - Steinman, Lawrence AU - Saito, Takashi AU - Locksley, Richard AU - Davis, Mark AU - Baumgarth, Nicole AU - Chien, Yueh-Hsiu PY - 2008/07/18/ UR - http://dx.doi.org/10.1016/j.immuni.2008.04.022 ER -