Slow vasomotor fluctuation in fMRI of anesthetized child brain

@article{citeulike:695672, abstract = {Signal intensity changes in fMRI during rest caused by vasomotor fluctuations were investigated in this work. Resting-state baseline fluctuations were evaluated in 12 children anesthetized with thiopental. Five subjects had fluctuations related to subvoxel motion. In seven subjects without significant motion, slow signal fluctuation at 0.025-0.041 Hz near one or more primary sensory cortices was observed. In each subject the amplitude and frequency of the fluctuations were stable. It is hypothesized that thiopental, which reduces blood pressure and flow in the cortex, alters the feedback in neurovascular coupling leading to an increase in the magnitude and a reduction in the frequency of these fluctuations. The use of anesthesia in fMRI may provide new insight into neural connectivity and the coupling of blood flow and neural metabolism. Magn Reson Med 44:373-378, 2000. {\copyright} 2000 Wiley-Liss, Inc.}, address = {Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; Department of Anesthesiology, Oulu University Hospital, Oulu, Finland; Department of Pediatrics, Oulu University Hospital, Oulu, Finland; Medical College of Wisconsin, Milwaukee, Wisconsin}, author = {Kiviniemi, Vesa and Jauhiainen, Jukka and Tervonen, Osmo and P\"{a}\"{a}kk\"{o}, Eija and Oikarinen, Jarkko and Vainionp\"{a}\"{a}, Vilho and Rantala, Heikki and Biswal, Bharat }, citeulike-article-id = {695672}, doi = {10.1002/1522-2594(200009)44:3<373::AID-MRM5>3.0.CO;2-P}, journal = {Magnetic Resonance in Medicine}, keywords = {lff}, number = {3}, pages = {373--378}, posted-at = {2007-12-26 10:06:01}, priority = {2}, title = {Slow vasomotor fluctuation in fMRI of anesthetized child brain}, url = {http://dx.doi.org/10.1002/1522-2594(200009)44:3\%3C373::AID-MRM5\%3E3.0.CO;2-P}, volume = {44}, year = {2000} }

TY - JOUR ID - citeulike:695672 L3 - citeulike-article-id:695672 TI - Slow vasomotor fluctuation in fMRI of anesthetized child brain JF - Magnetic Resonance in Medicine VL - 44 IS - 3 SP - 373 EP - 378 AD - Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; Department of Anesthesiology, Oulu University Hospital, Oulu, Finland; Department of Pediatrics, Oulu University Hospital, Oulu, Finland; Medical College of Wisconsin, Milwaukee, Wisconsin N2 - Signal intensity changes in fMRI during rest caused by vasomotor fluctuations were investigated in this work. Resting-state baseline fluctuations were evaluated in 12 children anesthetized with thiopental. Five subjects had fluctuations related to subvoxel motion. In seven subjects without significant motion, slow signal fluctuation at 0.025-0.041 Hz near one or more primary sensory cortices was observed. In each subject the amplitude and frequency of the fluctuations were stable. It is hypothesized that thiopental, which reduces blood pressure and flow in the cortex, alters the feedback in neurovascular coupling leading to an increase in the magnitude and a reduction in the frequency of these fluctuations. The use of anesthesia in fMRI may provide new insight into neural connectivity and the coupling of blood flow and neural metabolism. Magn Reson Med 44:373-378, 2000. © 2000 Wiley-Liss, Inc. KW - lff AU - Kiviniemi, Vesa AU - Jauhiainen, Jukka AU - Tervonen, Osmo AU - Pääkkö, Eija AU - Oikarinen, Jarkko AU - Vainionpää, Vilho AU - Rantala, Heikki AU - Biswal, Bharat PY - 2000/// UR - http://dx.doi.org/10.1002/1522-2594(200009)44:3%3C373::AID-MRM5%3E3.0.CO;2-P ER -