Treatment of acute otitis media with probiotics in otitis-prone children-A double-blind, placebo-controlled randomised study.

@article{citeulike:1165290, abstract = {BACKGROUND \& AIMS: To examine whether probiotics would reduce the occurrence or duration of acute otitis media (AOM), or the nasopharyngeal carriage of otitis pathogens in otitis-prone children. METHODS: During this double-blind, placebo-controlled, randomised, 24-week intervention, 309 otitis-prone children (10 months-6 years) consumed either one probiotic capsule (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve 99 and Propionibacterium freudenreichii JS) (n=155) or placebo (n=154) daily. Clinical examinations were carried out and nasopharyngeal samples taken three times. Parents recorded the symptoms of upper respiratory infection (URI) in a diary. RESULTS: Probiotic treatment did not reduce the occurrence (probiotic vs. placebo: 72\% vs. 65\%, OR=1.48, 95\% CI 0.87-2.52, p=n.s.) or the recurrence ( three) of AOM episodes (18\% vs. 17\%, OR=1.04, 95\% CI 0.55-1.96, p=n.s.). The median duration of AOM episodes was 5.6 (IQR 3.5-9.4) vs. 6.0 (IQR 4.0-10.5) days, respectively (p= n.s.). There was a tendency showing a reduction in the occurrence of recurrent (4 to 6) respiratory infections in the probiotic group (OR for 4 URIs: 0.56, 95\%CI 0.31-0.99, p=0.046; OR for 6 URIs: 0.59, 95\% CI 0.34 to 1.03, p=n.s.). Probiotics did not affect the carriage of Streptococcus pneumoniae or Haemophilus influenzae, but increased the prevalence of Moraxella catarrhalis (OR=1.79, 95\% CI 1.06-3.00, p=0.028). CONCLUSIONS: Probiotics did not prevent the occurrence of AOM or the nasopharyngeal carriage of otitis pathogens in otitis-prone children. A tendency showing a reduction in recurrent respiratory infections must be confirmed in further studies.}, address = {Valio Ltd, R\&D, P.O. Box. 30, FIN-00039 Helsinki, Finland; Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, P.O. Box.348, FIN-00029 Helsinki, Finland.}, author = {Hatakka, Katja and Blomgren, Karin and Pohjavuori, Sara and Kaijalainen, Tarja and Poussa, Tuija and Leinonen, Maija and Korpela, Riitta and Pitk\"{a}ranta, Anne }, citeulike-article-id = {1165290}, doi = {http://dx.doi.org/10.1016/j.clnu.2007.01.003}, issn = {0261-5614}, journal = {Clin Nutr}, month = {March}, posted-at = {2007-03-15 10:48:46}, priority = {2}, title = {Treatment of acute otitis media with probiotics in otitis-prone children-A double-blind, placebo-controlled randomised study.}, url = {http://dx.doi.org/10.1016/j.clnu.2007.01.003}, year = {2007} }

TY - JOUR ID - citeulike:1165290 L3 - citeulike-article-id:1165290 TI - Treatment of acute otitis media with probiotics in otitis-prone children-A double-blind, placebo-controlled randomised study. JF - Clin Nutr AD - Valio Ltd, R&D, P.O. Box. 30, FIN-00039 Helsinki, Finland; Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, P.O. Box.348, FIN-00029 Helsinki, Finland. SN - 0261-5614 N2 - BACKGROUND & AIMS: To examine whether probiotics would reduce the occurrence or duration of acute otitis media (AOM), or the nasopharyngeal carriage of otitis pathogens in otitis-prone children. METHODS: During this double-blind, placebo-controlled, randomised, 24-week intervention, 309 otitis-prone children (10 months-6 years) consumed either one probiotic capsule (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve 99 and Propionibacterium freudenreichii JS) (n=155) or placebo (n=154) daily. Clinical examinations were carried out and nasopharyngeal samples taken three times. Parents recorded the symptoms of upper respiratory infection (URI) in a diary. RESULTS: Probiotic treatment did not reduce the occurrence (probiotic vs. placebo: 72% vs. 65%, OR=1.48, 95% CI 0.87-2.52, p=n.s.) or the recurrence ( three) of AOM episodes (18% vs. 17%, OR=1.04, 95% CI 0.55-1.96, p=n.s.). The median duration of AOM episodes was 5.6 (IQR 3.5-9.4) vs. 6.0 (IQR 4.0-10.5) days, respectively (p= n.s.). There was a tendency showing a reduction in the occurrence of recurrent (4 to 6) respiratory infections in the probiotic group (OR for 4 URIs: 0.56, 95%CI 0.31-0.99, p=0.046; OR for 6 URIs: 0.59, 95% CI 0.34 to 1.03, p=n.s.). Probiotics did not affect the carriage of Streptococcus pneumoniae or Haemophilus influenzae, but increased the prevalence of Moraxella catarrhalis (OR=1.79, 95% CI 1.06-3.00, p=0.028). CONCLUSIONS: Probiotics did not prevent the occurrence of AOM or the nasopharyngeal carriage of otitis pathogens in otitis-prone children. A tendency showing a reduction in recurrent respiratory infections must be confirmed in further studies. AU - Hatakka, Katja AU - Blomgren, Karin AU - Pohjavuori, Sara AU - Kaijalainen, Tarja AU - Poussa, Tuija AU - Leinonen, Maija AU - Korpela, Riitta AU - Pitkäranta, Anne PY - 2007/03/10/ UR - http://dx.doi.org/10.1016/j.clnu.2007.01.003 ER -