Features of selective kinase inhibitors.

@article{citeulike:320041, abstract = {Small-molecule inhibitors of protein and lipid kinases have emerged as indispensable tools for studying signal transduction. Despite the widespread use of these reagents, there is little consensus about the biochemical criteria that define their potency and selectivity in cells. We discuss some of the features that determine the cellular activity of kinase inhibitors and propose a framework for interpreting inhibitor selectivity.}, address = {Program in Chemistry and Chemical Biology, University of California-San Francisco, San Francisco, CA 94143, USA.}, author = {Knight, Z. A. and Shokat, K. M. }, citeulike-article-id = {320041}, doi = {10.1016/j.chembiol.2005.04.011}, issn = {1074-5521}, journal = {Chem Biol}, keywords = {chemical, drugdiscovery, inhibitor, kinase, review}, month = {June}, number = {6}, pages = {621--637}, posted-at = {2006-05-28 16:33:09}, priority = {0}, title = {Features of selective kinase inhibitors.}, url = {http://dx.doi.org/10.1016/j.chembiol.2005.04.011}, volume = {12}, year = {2005} }

TY - JOUR ID - citeulike:320041 L3 - citeulike-article-id:320041 TI - Features of selective kinase inhibitors. JF - Chem Biol VL - 12 IS - 6 SP - 621 EP - 637 AD - Program in Chemistry and Chemical Biology, University of California-San Francisco, San Francisco, CA 94143, USA. SN - 1074-5521 N2 - Small-molecule inhibitors of protein and lipid kinases have emerged as indispensable tools for studying signal transduction. Despite the widespread use of these reagents, there is little consensus about the biochemical criteria that define their potency and selectivity in cells. We discuss some of the features that determine the cellular activity of kinase inhibitors and propose a framework for interpreting inhibitor selectivity. KW - chemical KW - drugdiscovery KW - inhibitor KW - kinase KW - review AU - Knight, ZA AU - Shokat, KM PY - 2005/06// UR - http://dx.doi.org/10.1016/j.chembiol.2005.04.011 ER -