Addiction and the brain: the neurobiology of compulsion and its persistence.

@article{citeulike:673473, abstract = {People take addictive drugs to elevate mood, but with repeated use these drugs produce serious unwanted effects, which can include tolerance to some drug effects, sensitization to others, and an adapted state - dependence - which sets the stage for withdrawal symptoms when drug use stops. The most serious consequence of repetitive drug taking, however, is addiction: a persistent state in which compulsive drug use escapes control, even when serious negative consequences ensue. Addiction is characterized by a long-lasting risk of relapse, which is often initiated by exposure to drug-related cues. Substantial progress has been made in understanding the molecular and cellular mechanisms of tolerance, dependence and withdrawal, but as yet we understand little of the neural substrates of compulsive drug use and its remarkable persistence. Here we review evidence for the possibility that compulsion and its persistence are based on a pathological usurpation of molecular mechanisms that are normally involved in memory.}, address = {National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, Maryland 20892-9669, USA. shyman@nih.gov}, author = {Hyman, S. E. and Malenka, R. C. }, citeulike-article-id = {673473}, comment = {Very interesting article on addiction}, doi = {http://dx.doi.org/10.1038/35094560}, issn = {1471-003X}, journal = {Nat Rev Neurosci}, keywords = {addiction, review}, month = {October}, number = {10}, pages = {695--703}, posted-at = {2006-05-28 16:25:27}, priority = {0}, title = {Addiction and the brain: the neurobiology of compulsion and its persistence.}, url = {http://dx.doi.org/10.1038/35094560}, volume = {2}, year = {2001} }

TY - JOUR ID - citeulike:673473 L3 - citeulike-article-id:673473 N2 - People take addictive drugs to elevate mood, but with repeated use these drugs produce serious unwanted effects, which can include tolerance to some drug effects, sensitization to others, and an adapted state - dependence - which sets the stage for withdrawal symptoms when drug use stops. The most serious consequence of repetitive drug taking, however, is addiction: a persistent state in which compulsive drug use escapes control, even when serious negative consequences ensue. Addiction is characterized by a long-lasting risk of relapse, which is often initiated by exposure to drug-related cues. Substantial progress has been made in understanding the molecular and cellular mechanisms of tolerance, dependence and withdrawal, but as yet we understand little of the neural substrates of compulsive drug use and its remarkable persistence. Here we review evidence for the possibility that compulsion and its persistence are based on a pathological usurpation of molecular mechanisms that are normally involved in memory. IS - 10 JF - Nat Rev Neurosci SN - 1471-003X AD - National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, Maryland 20892-9669, USA. shyman@nih.gov EP - 703 TI - Addiction and the brain: the neurobiology of compulsion and its persistence. VL - 2 SP - 695 KW - addiction KW - review N1 - Very interesting article on addiction AU - Hyman, SE AU - Malenka, RC PY - 2001/10// UR - http://dx.doi.org/10.1038/35094560 ER -