Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons.

@article{citeulike:2202888, abstract = {Long-term plasticity of dendritic integration is induced in parallel with long-term potentiation (LTP) or depression (LTD) based on presynaptic activity patterns. It is however not clear whether synaptic plasticity induced by temporal pairing of pre- and post-synaptic activity is also associated with synergistic modification in dendritic integration. We show here that the spike-timing-dependent plasticity (STDP) rule accounts for long-term changes in dendritic integration in CA1 pyramidal neurons in vitro. Positively correlated pre- and post-synaptic activity (delay: +5/+50 ms) induced LTP and facilitated dendritic integration. Negatively correlated activity (delay: -5/-50 ms) induced LTD and depressed dendritic integration. These changes were not observed following positive or negative pairing with long delays (f(R) "b50 ms) or when NMDA receptors were blocked. The amplitude-slope relation of the EPSP was facilitated after LTP and depressed after LTD. These effects could be mimicked by voltage-gated channel blockers, suggesting that the induced changes in EPSP waveform involve the regulation of voltage-gated channel activity. Importantly, amplitude-slope changes induced by STDP were found to be input specific, indicating that the underlying changes in excitability are restricted to a limited portion of the dendrites. We conclude that STDP is a common learning rule for long-term plasticity of both synaptic transmission and dendritic integration, thus constituting a form of functional redundancy that insures significant changes in the neuronal output when synaptic plasticity is induced.}, address = {INSERM.}, author = {Campanac, Emilie and Debanne, Dominique }, citeulike-article-id = {2202888}, doi = {10.1113/jphysiol.2007.147017}, issn = {0022-3751}, journal = {J Physiol}, keywords = {ca1, stdp}, month = {November}, posted-at = {2008-04-30 12:35:53}, priority = {5}, title = {Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons.}, url = {http://dx.doi.org/10.1113/jphysiol.2007.147017}, year = {2007} }

TY - JOUR ID - citeulike:2202888 L3 - citeulike-article-id:2202888 TI - Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons. JF - J Physiol AD - INSERM. SN - 0022-3751 N2 - Long-term plasticity of dendritic integration is induced in parallel with long-term potentiation (LTP) or depression (LTD) based on presynaptic activity patterns. It is however not clear whether synaptic plasticity induced by temporal pairing of pre- and post-synaptic activity is also associated with synergistic modification in dendritic integration. We show here that the spike-timing-dependent plasticity (STDP) rule accounts for long-term changes in dendritic integration in CA1 pyramidal neurons in vitro. Positively correlated pre- and post-synaptic activity (delay: +5/+50 ms) induced LTP and facilitated dendritic integration. Negatively correlated activity (delay: -5/-50 ms) induced LTD and depressed dendritic integration. These changes were not observed following positive or negative pairing with long delays (f(R) "b50 ms) or when NMDA receptors were blocked. The amplitude-slope relation of the EPSP was facilitated after LTP and depressed after LTD. These effects could be mimicked by voltage-gated channel blockers, suggesting that the induced changes in EPSP waveform involve the regulation of voltage-gated channel activity. Importantly, amplitude-slope changes induced by STDP were found to be input specific, indicating that the underlying changes in excitability are restricted to a limited portion of the dendrites. We conclude that STDP is a common learning rule for long-term plasticity of both synaptic transmission and dendritic integration, thus constituting a form of functional redundancy that insures significant changes in the neuronal output when synaptic plasticity is induced. KW - ca1 KW - stdp AU - Campanac, Emilie AU - Debanne, Dominique PY - 2007/11/29/ UR - http://dx.doi.org/10.1113/jphysiol.2007.147017 ER -