Cortical development and remapping through spike timing-dependent plasticity.

@article{citeulike:2731254, abstract = {Long-term modification of synaptic efficacy can depend on the timing of pre- and postsynaptic action potentials. In model studies, such spike timing-dependent plasticity (STDP) introduces the desirable features of competition among synapses and regulation of postsynaptic firing characteristics. STDP strengthens synapses that receive correlated input, which can lead to the formation of stimulus-selective columns and the development, refinement, and maintenance of selectivity maps in network models. The temporal asymmetry of STDP suppresses strong destabilizing self-excitatory loops and allows a group of neurons that become selective early in development to direct other neurons to become similarly selective. STDP, acting alone without further hypothetical global constraints or additional forms of plasticity, can also reproduce the remapping seen in adult cortex following afferent lesions.}, address = {Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, MA 02454-9110, USA.}, author = {Song, S. and Abbott, L. F. }, citeulike-article-id = {2731254}, issn = {0896-6273}, journal = {Neuron}, keywords = {stdp}, month = {October}, number = {2}, pages = {339--350}, posted-at = {2008-04-29 00:03:43}, priority = {2}, title = {Cortical development and remapping through spike timing-dependent plasticity.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11684002}, volume = {32}, year = {2001} }

TY - JOUR ID - citeulike:2731254 L3 - citeulike-article-id:2731254 TI - Cortical development and remapping through spike timing-dependent plasticity. JF - Neuron VL - 32 IS - 2 SP - 339 EP - 350 AD - Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, MA 02454-9110, USA. SN - 0896-6273 N2 - Long-term modification of synaptic efficacy can depend on the timing of pre- and postsynaptic action potentials. In model studies, such spike timing-dependent plasticity (STDP) introduces the desirable features of competition among synapses and regulation of postsynaptic firing characteristics. STDP strengthens synapses that receive correlated input, which can lead to the formation of stimulus-selective columns and the development, refinement, and maintenance of selectivity maps in network models. The temporal asymmetry of STDP suppresses strong destabilizing self-excitatory loops and allows a group of neurons that become selective early in development to direct other neurons to become similarly selective. STDP, acting alone without further hypothetical global constraints or additional forms of plasticity, can also reproduce the remapping seen in adult cortex following afferent lesions. KW - stdp AU - Song, S AU - Abbott, LF PY - 2001/10/25/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11684002 ER -