Dependence of EPSP efficacy on synapse location in neocortical pyramidal neurons.

by: SR Williams, GJ Stuart

Science, Vol. 295, No. 5561. (8 March 2002), pp. 1907-1910.

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Abstract

Neurons receive thousands of synaptic inputs throughout elaborate dendritic trees. Here we determine the somatic impact of excitatory postsynaptic potentials (EPSPs) generated at known dendritic sites in neocortical pyramidal neurons. As inputs became more distal, somatic EPSP amplitude decreased, whereas use-dependent depression increased. Despite marked attenuation (>40-fold), when coactivated within a narrow time window (approximately 10 milliseconds), distal EPSPs could directly influence action potential output following dendritic spike generation. These findings reveal that distal EPSPs are ineffective sources of background somatic excitation, but through coincidence detection have a powerful transient signaling role.

@article{citeulike:316667, abstract = {Neurons receive thousands of synaptic inputs throughout elaborate dendritic trees. Here we determine the somatic impact of excitatory postsynaptic potentials (EPSPs) generated at known dendritic sites in neocortical pyramidal neurons. As inputs became more distal, somatic EPSP amplitude decreased, whereas use-dependent depression increased. Despite marked attenuation (>40-fold), when coactivated within a narrow time window (approximately 10 milliseconds), distal EPSPs could directly influence action potential output following dendritic spike generation. These findings reveal that distal EPSPs are ineffective sources of background somatic excitation, but through coincidence detection have a powerful transient signaling role.}, address = {Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.}, author = {Williams, S. R. and Stuart, G. J. }, citeulike-article-id = {316667}, doi = {10.1126/science.1067903}, issn = {1095-9203}, journal = {Science}, keywords = {stdp}, month = {March}, number = {5561}, pages = {1907--1910}, posted-at = {2008-04-29 00:11:56}, priority = {2}, title = {Dependence of EPSP efficacy on synapse location in neocortical pyramidal neurons.}, url = {http://dx.doi.org/10.1126/science.1067903}, volume = {295}, year = {2002} }

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TY - JOUR ID - citeulike:316667 L3 - citeulike-article-id:316667 TI - Dependence of EPSP efficacy on synapse location in neocortical pyramidal neurons. JF - Science VL - 295 IS - 5561 SP - 1907 EP - 1910 AD - Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia. SN - 1095-9203 N2 - Neurons receive thousands of synaptic inputs throughout elaborate dendritic trees. Here we determine the somatic impact of excitatory postsynaptic potentials (EPSPs) generated at known dendritic sites in neocortical pyramidal neurons. As inputs became more distal, somatic EPSP amplitude decreased, whereas use-dependent depression increased. Despite marked attenuation (>40-fold), when coactivated within a narrow time window (approximately 10 milliseconds), distal EPSPs could directly influence action potential output following dendritic spike generation. These findings reveal that distal EPSPs are ineffective sources of background somatic excitation, but through coincidence detection have a powerful transient signaling role. KW - stdp AU - Williams, SR AU - Stuart, GJ PY - 2002/03/08/ UR - http://dx.doi.org/10.1126/science.1067903 ER -

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