Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae.

@article{citeulike:1713649, abstract = {It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono- and polyphosphorylated adducts to the inositol ring in PtdIns), which are located at the cytoplasmic face of cellular membranes. Phosphoinositides serve both a structural and a signaling role via their recruitment of proteins that contain phosphoinositide-binding domains. Phosphoinositides also have a role as precursors of several types of second messengers for certain intracellular signaling pathways. Realization of the importance of phosphoinositides has brought increased attention to characterization of the enzymes that regulate their synthesis, interconversion, and turnover. Here we review the current state of our knowledge about the properties and regulation of the ATP-dependent lipid kinases responsible for synthesis of phosphoinositides and also the additional temporal and spatial controls exerted by the phosphatases and a phospholipase that act on phosphoinositides in yeast.}, address = {Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.}, author = {Strahl, T. and Thorner, J. }, citeulike-article-id = {1713649}, doi = {10.1016/j.bbalip.2007.01.015}, issn = {0006-3002}, journal = {Biochim Biophys Acta}, keywords = {enzyme, regulation}, month = {March}, number = {3}, pages = {353--404}, posted-at = {2007-10-01 05:48:40}, priority = {2}, title = {Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae.}, url = {http://dx.doi.org/10.1016/j.bbalip.2007.01.015}, volume = {1771}, year = {2007} }

TY - JOUR ID - citeulike:1713649 L3 - citeulike-article-id:1713649 TI - Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. JF - Biochim Biophys Acta VL - 1771 IS - 3 SP - 353 EP - 404 AD - Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. SN - 0006-3002 N2 - It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono- and polyphosphorylated adducts to the inositol ring in PtdIns), which are located at the cytoplasmic face of cellular membranes. Phosphoinositides serve both a structural and a signaling role via their recruitment of proteins that contain phosphoinositide-binding domains. Phosphoinositides also have a role as precursors of several types of second messengers for certain intracellular signaling pathways. Realization of the importance of phosphoinositides has brought increased attention to characterization of the enzymes that regulate their synthesis, interconversion, and turnover. Here we review the current state of our knowledge about the properties and regulation of the ATP-dependent lipid kinases responsible for synthesis of phosphoinositides and also the additional temporal and spatial controls exerted by the phosphatases and a phospholipase that act on phosphoinositides in yeast. KW - enzyme KW - regulation AU - Strahl, T AU - Thorner, J PY - 2007/03// UR - http://dx.doi.org/10.1016/j.bbalip.2007.01.015 ER -