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MOLECULAR BIOLOGY: miRNAs in Neurodegeneration

by: Sebastien S Hebert, Bart De Strooper

Science, Vol. 317, No. 5842. (31 August 2007), pp. 1179-1180.

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10.1126/science.1148530

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21u-rna 3 454 5 5utr activation ago2 ago4 alignment alternative alternativesplicing alu analysis animal animals antagomirs antitarget arabidopsis argonautes arms array asymmetry atlas bayes bayesian bayesmirnafind binding biogenisis biological biology body brain brassica canalization cancer capbindingmotif cds cell cell-cycle cervical characteristics chimpanzee chip chip-chip chlamydomonas chromatin chromatoid classification classifier cleavage cloning clustering clusters combinatorial common comparative comparison competition comporative computational consensus conservation conserved cooperativity cotton cpg crystalstructure database dcl1 deadenylation defense delivery detection development dgcr8 dicer discovery disease distance-dependent distribution divergence dna dominant drosha drosophila dsrna dynamic editing elegans element elements encode energy epbv epigenetics epigentics est eukaryotes evolution experimental export expression factors families family features feedbackloop folding free function functional gene geneact genome genomes genomic genomics germ guide-rna hairpin heart hen1 hepatitisc herpes hippocampus hiv hnrnp homology hox human hyl1 hypothalamus identification import in inhibition intron inverted-repeat invitro japonica knockout learning let7 lii lipid-metabolism liver lna loading localized-effect locarna location machine maize mammal mammalian mammals maternal mattick mechanism mechanisms metazoan method methylation microarray microrna mimicry mir-122 mir124 mir-133 mir155 mir164 mir-200b mir-208 mir21 mir24 mir34 mir-34 mir375 mir7 mirbase mirgen mirna mirnas mirnomics mirtron modules motif mouse mpss mrna multicopy multifunction multiple multi-species mus muscle naive napus ncrna nervous-system network neurodegeneration neuron nonconservation nonconserved non-conserved nuclear oncogene opossum origin overhang p53 pact pancreas pancreatic pasha pathway perpective perspective phenotype phylogeny pirna plant plants polya polycomb polymeraseii polymorphism populus post-transcriptional poymerase ppi precurso precursor prediction pri pri-mirna processing production profile promoter protein-dna-interactions proximal pseudogene p-value pyknons rake rat rckp54 rde-4 rdr6 reduncancy regulation repeat repeats repression resistence review rice risc rna rna22 rnacast rnadb rnai rnarna rnashapes rnasiii rnaup rnaz robustness rules saco sage sampling schizophrenia sde5 seed selfish sequences serrate service shrna shuffling silence silencing single-cell single-target-site-phenotype sirna site snp sorting spatial specialization splicing sponges stability star statistics stem stress structural structure suffix svm target target-protector targets targetsite tasirna ta-sirna tf therapeutic therapeutics thermodynamic tissue transcription translation translational transposable transposon transposon-free tumorsuppressor ultraconserved utr variation vertebrate virus viruses vitro web xenopus yeast zebrafish