Computational analysis of microRNA-mediated antiviral defense in humans.

by: Yuka Watanabe, Atsuko Kishi, Nozomu Yachie, Akio Kanai, Masaru Tomita

FEBS Lett (31 August 2007)

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Abstract

Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans.

@article{citeulike:1645037, abstract = {Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans.}, address = {Institute for Advanced Biosciences, Keio University, Tsuruoka 997-0017, Japan; Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa 252-8520, Japan.}, author = {Watanabe, Yuka and Kishi, Atsuko and Yachie, Nozomu and Kanai, Akio and Tomita, Masaru }, citeulike-article-id = {1645037}, doi = {10.1016/j.febslet.2007.08.049}, issn = {0014-5793}, journal = {FEBS Lett}, keywords = {defense, human, mirna, virus}, month = {August}, posted-at = {2007-09-11 18:54:42}, priority = {2}, title = {Computational analysis of microRNA-mediated antiviral defense in humans.}, url = {http://dx.doi.org/10.1016/j.febslet.2007.08.049}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1645037 L3 - citeulike-article-id:1645037 TI - Computational analysis of microRNA-mediated antiviral defense in humans. JF - FEBS Lett AD - Institute for Advanced Biosciences, Keio University, Tsuruoka 997-0017, Japan; Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa 252-8520, Japan. SN - 0014-5793 N2 - Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans. KW - defense KW - human KW - mirna KW - virus AU - Watanabe, Yuka AU - Kishi, Atsuko AU - Yachie, Nozomu AU - Kanai, Akio AU - Tomita, Masaru PY - 2007/08/31/ UR - http://dx.doi.org/10.1016/j.febslet.2007.08.049 ER -

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