NMDA Receptor-dependent Long-term Potentiation in the Hippocampal Afferent Fibre System to the Prefrontal Cortex in the Rat

@article{Jay1995, abstract = {Abstract This study investigated the role of the N-methyl-d-aspartate (NMDA) subtype of glutamate receptor in the induction of long-term potentiation (LTP) in the hippocampal-prefrontal cortex pathway in vivo. Field potentials evoked by electrical stimulation of the CA1/subicular region were recorded in the prelimbic area of the prefrontal cortex under continuous perfusion of artificial cerebrospinal fluid in anaesthetized rats. High-frequency stimulation of the CA1/subicular region induced LTP of the evoked response in the prelimbic area of the prefrontal cortex. LTP was completely blocked when the selective NMDA receptor antagonist d-(-)2-amino-5- phosphonopentanoic acid (d-AP5; 200 muM), was perfused during the tetanus. Perfusion of D-AP5 did not affect normal transmission or pre-established LTP. These results demonstrate that induction of LTP in the hippocampal-prefrontal cortex pathway is an NMDA receptor-dependent process.}, author = {Jay, Therese M. and Burette, Francois and Laroche, Serge }, citeulike-article-id = {2648747}, doi = {10.1111/j.1460-9568.1995.tb01060.x}, journal = {European Journal of Neuroscience}, keywords = {hippocampus, ltp, nmda, pfc}, number = {2}, pages = {247--250}, posted-at = {2008-04-10 10:31:00}, priority = {2}, title = {NMDA Receptor-dependent Long-term Potentiation in the Hippocampal Afferent Fibre System to the Prefrontal Cortex in the Rat}, url = {http://www.blackwell-synergy.com/doi/abs/10.1111/j.1460-9568.1995.tb01060.x}, volume = {7}, year = {1995} }

TY - JOUR ID - Jay1995 L3 - citeulike-article-id:2648747 TI - NMDA Receptor-dependent Long-term Potentiation in the Hippocampal Afferent Fibre System to the Prefrontal Cortex in the Rat JF - European Journal of Neuroscience VL - 7 IS - 2 SP - 247 EP - 250 N2 - Abstract This study investigated the role of the N-methyl-d-aspartate (NMDA) subtype of glutamate receptor in the induction of long-term potentiation (LTP) in the hippocampal-prefrontal cortex pathway in vivo. Field potentials evoked by electrical stimulation of the CA1/subicular region were recorded in the prelimbic area of the prefrontal cortex under continuous perfusion of artificial cerebrospinal fluid in anaesthetized rats. High-frequency stimulation of the CA1/subicular region induced LTP of the evoked response in the prelimbic area of the prefrontal cortex. LTP was completely blocked when the selective NMDA receptor antagonist d-(-)2-amino-5- phosphonopentanoic acid (d-AP5; 200 muM), was perfused during the tetanus. Perfusion of D-AP5 did not affect normal transmission or pre-established LTP. These results demonstrate that induction of LTP in the hippocampal-prefrontal cortex pathway is an NMDA receptor-dependent process. KW - hippocampus KW - ltp KW - nmda KW - pfc AU - Jay, Therese AU - Burette, Francois AU - Laroche, Serge PY - 1995/// UR - http://www.blackwell-synergy.com/doi/abs/10.1111/j.1460-9568.1995.tb01060.x ER -