How Visual Stimuli Activate Dopaminergic Neurons at Short Latency

by: Eleanor Dommett, Veronique Coizet, Charles D Blaha, John Martindale, Veronique Lefebvre, Natalie Walton, John E Mayhew, Paul G Overton, Peter Redgrave

Science, Vol. 307, No. 5714. (04 March 2005), pp. 1476-1479.

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Abstract

Unexpected, biologically salient stimuli elicit a short-latency, phasic response in midbrain dopaminergic (DA) neurons. Although this signal is important for reinforcement learning, the information it conveys to forebrain target structures remains uncertain. One way to decode the phasic DA signal would be to determine the perceptual properties of sensory inputs to DA neurons. After local disinhibition of the superior colliculus in anesthetized rats, DA neurons became visually responsive, whereas disinhibition of the visual cortex was ineffective. As the primary source of visual afferents, the limited processing capacities of the colliculus may constrain the visual information content of phasic DA responses.

@article{citeulike:113984, abstract = {Unexpected, biologically salient stimuli elicit a short-latency, phasic response in midbrain dopaminergic (DA) neurons. Although this signal is important for reinforcement learning, the information it conveys to forebrain target structures remains uncertain. One way to decode the phasic DA signal would be to determine the perceptual properties of sensory inputs to DA neurons. After local disinhibition of the superior colliculus in anesthetized rats, DA neurons became visually responsive, whereas disinhibition of the visual cortex was ineffective. As the primary source of visual afferents, the limited processing capacities of the colliculus may constrain the visual information content of phasic DA responses.}, author = {Dommett, Eleanor and Coizet, Veronique and Blaha, Charles D. and Martindale, John and Lefebvre, Veronique and Walton, Natalie and Mayhew, John E. and Overton, Paul G. and Redgrave, Peter }, citeulike-article-id = {113984}, doi = {http://dx.doi.org/10.1126/science.1107026}, journal = {Science}, keywords = {dopamine, substantia-nigra, superior-colliculus, vta}, month = {March}, number = {5714}, pages = {1476--1479}, posted-at = {2007-03-28 14:08:14}, priority = {0}, title = {How Visual Stimuli Activate Dopaminergic Neurons at Short Latency}, url = {http://dx.doi.org/10.1126/science.1107026}, volume = {307}, year = {2005} }

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TY - JOUR ID - citeulike:113984 L3 - citeulike-article-id:113984 TI - How Visual Stimuli Activate Dopaminergic Neurons at Short Latency JF - Science VL - 307 IS - 5714 SP - 1476 EP - 1479 N2 - Unexpected, biologically salient stimuli elicit a short-latency, phasic response in midbrain dopaminergic (DA) neurons. Although this signal is important for reinforcement learning, the information it conveys to forebrain target structures remains uncertain. One way to decode the phasic DA signal would be to determine the perceptual properties of sensory inputs to DA neurons. After local disinhibition of the superior colliculus in anesthetized rats, DA neurons became visually responsive, whereas disinhibition of the visual cortex was ineffective. As the primary source of visual afferents, the limited processing capacities of the colliculus may constrain the visual information content of phasic DA responses. KW - dopamine KW - substantia-nigra KW - superior-colliculus KW - vta AU - Dommett, Eleanor AU - Coizet, Veronique AU - Blaha, Charles AU - Martindale, John AU - Lefebvre, Veronique AU - Walton, Natalie AU - Mayhew, John AU - Overton, Paul AU - Redgrave, Peter PY - 2005/03/04/ UR - http://dx.doi.org/10.1126/science.1107026 ER -

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