Dopamine receptor signaling.

@article{citeulike:1273442, abstract = {The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling properties that contribute to the definition of the receptor class, although some differences among subtypes within a class have been identified. D1-like receptor signaling is mediated chiefly by the heterotrimeric G proteins Galphas and Galphaolf, which cause sequential activation of adenylate cyclase, cylic AMP-dependent protein kinase, and the protein phosphatase-1 inhibitor DARPP-32. The increased phosphorylation that results from the combined effects of activating cyclic AMP-dependent protein kinase and inhibiting protein phosphatase 1 regulates the activity of many receptors, enzymes, ion channels, and transcription factors. D1 or a novel D1-like receptor also signals via phospholipase C-dependent and cyclic AMP-independent mobilization of intracellular calcium. D2-like receptor signaling is mediated by the heterotrimeric G proteins Galphai and Galphao. These pertussis toxin-sensitive G proteins regulate some effectors, such as adenylate cyclase, via their Galpha subunits, but regulate many more effectors such as ion channels, phospholipases, protein kinases, and receptor tyrosine kinases as a result of the receptor-induced liberation of Gbetagamma subunits. In addition to interactions between dopamine receptors and G proteins, other protein:protein interactions such as receptor oligomerization or receptor interactions with scaffolding and signal-switching proteins are critical for regulation of dopamine receptor signaling.}, address = {Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA. nevek@ohsu.edu}, author = {Neve, K. A. and Seamans, J. K. and Trantham-Davidson, H. }, citeulike-article-id = {1273442}, issn = {1079-9893}, journal = {J Recept Signal Transduct Res}, keywords = {dopamine, intracellular-cascades, neuromodulation, receptors}, month = {August}, number = {3}, pages = {165--205}, posted-at = {2007-05-03 10:32:26}, priority = {0}, title = {Dopamine receptor signaling.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15521361}, volume = {24}, year = {2004} }

TY - JOUR ID - citeulike:1273442 L3 - citeulike-article-id:1273442 TI - Dopamine receptor signaling. JF - J Recept Signal Transduct Res VL - 24 IS - 3 SP - 165 EP - 205 AD - Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA. nevek@ohsu.edu SN - 1079-9893 N2 - The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling properties that contribute to the definition of the receptor class, although some differences among subtypes within a class have been identified. D1-like receptor signaling is mediated chiefly by the heterotrimeric G proteins Galphas and Galphaolf, which cause sequential activation of adenylate cyclase, cylic AMP-dependent protein kinase, and the protein phosphatase-1 inhibitor DARPP-32. The increased phosphorylation that results from the combined effects of activating cyclic AMP-dependent protein kinase and inhibiting protein phosphatase 1 regulates the activity of many receptors, enzymes, ion channels, and transcription factors. D1 or a novel D1-like receptor also signals via phospholipase C-dependent and cyclic AMP-independent mobilization of intracellular calcium. D2-like receptor signaling is mediated by the heterotrimeric G proteins Galphai and Galphao. These pertussis toxin-sensitive G proteins regulate some effectors, such as adenylate cyclase, via their Galpha subunits, but regulate many more effectors such as ion channels, phospholipases, protein kinases, and receptor tyrosine kinases as a result of the receptor-induced liberation of Gbetagamma subunits. In addition to interactions between dopamine receptors and G proteins, other protein:protein interactions such as receptor oligomerization or receptor interactions with scaffolding and signal-switching proteins are critical for regulation of dopamine receptor signaling. KW - dopamine KW - intracellular-cascades KW - neuromodulation KW - receptors AU - Neve, KA AU - Seamans, JK AU - Trantham-Davidson, H PY - 2004/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/15521361 ER -