Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement.

@article{citeulike:1277630, abstract = {Ventral tegmental area (VTA) neuron firing precedes behaviors elicited by reward-predictive sensory cues and scales with the magnitude and unpredictability of received rewards. These patterns are consistent with roles in the performance of learned appetitive behaviors and in positive reinforcement, respectively. The VTA includes subpopulations of neurons with different afferent connections, neurotransmitter content, and projection targets. Because the VTA and substantia nigra pars compacta are the sole sources of striatal and limbic forebrain dopamine, measurements of dopamine release and manipulations of dopamine function have provided critical evidence supporting a VTA contribution to these functions. However, the VTA also sends GABAergic and glutamatergic projections to the nucleus accumbens and prefrontal cortex. Furthermore,VTAmediated but dopamine-independent positive reinforcement has been demonstrated. Consequently, identifying the neurotransmitter content and projection target of VTA neurons recorded in vivo will be critical for determining their contribution to learned appetitive behaviors. Expected online publication date for the Annual Review of Neuroscience Volume 30 is June 16, 2007. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.}, address = {Ernest Gallo Clinic and Research Center and Wheeler Center for the Neurobiology of Addiction, University of California, San Francisco, Emeryville, California 94608 hlf@phy.ucsf.edu.}, author = {Fields, Howard L L. and Hjelmstad, Gregory O O. and Margolis, Elyssa B B. and Nicola, Saleem M M. }, citeulike-article-id = {1277630}, doi = {http://dx.doi.org/10.1146/annurev.neuro.30.051606.094341}, issn = {0147-006X}, journal = {Annu Rev Neurosci}, keywords = {dopamine, gaba, glutamate, nucleus-accumbens, prefrontal-cortex, review, vta}, month = {March}, posted-at = {2007-06-19 13:20:37}, priority = {0}, title = {Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement.}, url = {http://dx.doi.org/10.1146/annurev.neuro.30.051606.094341}, year = {2007} }

TY - JOUR ID - citeulike:1277630 L3 - citeulike-article-id:1277630 TI - Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement. JF - Annu Rev Neurosci AD - Ernest Gallo Clinic and Research Center and Wheeler Center for the Neurobiology of Addiction, University of California, San Francisco, Emeryville, California 94608 hlf@phy.ucsf.edu. SN - 0147-006X N2 - Ventral tegmental area (VTA) neuron firing precedes behaviors elicited by reward-predictive sensory cues and scales with the magnitude and unpredictability of received rewards. These patterns are consistent with roles in the performance of learned appetitive behaviors and in positive reinforcement, respectively. The VTA includes subpopulations of neurons with different afferent connections, neurotransmitter content, and projection targets. Because the VTA and substantia nigra pars compacta are the sole sources of striatal and limbic forebrain dopamine, measurements of dopamine release and manipulations of dopamine function have provided critical evidence supporting a VTA contribution to these functions. However, the VTA also sends GABAergic and glutamatergic projections to the nucleus accumbens and prefrontal cortex. Furthermore,VTAmediated but dopamine-independent positive reinforcement has been demonstrated. Consequently, identifying the neurotransmitter content and projection target of VTA neurons recorded in vivo will be critical for determining their contribution to learned appetitive behaviors. Expected online publication date for the Annual Review of Neuroscience Volume 30 is June 16, 2007. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. KW - dopamine KW - gaba KW - glutamate KW - nucleus-accumbens KW - prefrontal-cortex KW - review KW - vta AU - Fields, Howard L AU - Hjelmstad, Gregory O AU - Margolis, Elyssa B AU - Nicola, Saleem M PY - 2007/03/15/ UR - http://dx.doi.org/10.1146/annurev.neuro.30.051606.094341 ER -