Acetylcholine Release in Ventral Tegmental Area by Hypothalamic Self-Stimulation, Eating, and Drinking

by: Pedro V Rada, Gregory P Mark, John J Yeomans, Bartley G Hoebel

Pharmacology Biochemistry and Behavior, Vol. 65, No. 3. (March 2000), pp. 375-379.

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Abstract

Evidence is presented for an acetylcholine (ACh) input to the midbrain ventral tegmental area (VTA) as part of a system for self-stimulation and ingestive behavior. Male rats were prepared with an electrode in the perifornical lateral hypothalamus and an ipsilateral guideshaft for microdialysis in the VTA. Extracellular ACh increased in the VTA during self-stimulation, auto-stimulation, eating, or drinking. Infusion of atropine into the VTA via the microdialysis probe was sufficient to stop self-stimulation and reduce intake of food. It is concluded that ACh acts at muscarinic receptors in the VTA as part of a circuit that modulates hypothalamic self-stimulation and ingestive behavior.

@article{citeulike:1597285, abstract = {Evidence is presented for an acetylcholine (ACh) input to the midbrain ventral tegmental area (VTA) as part of a system for self-stimulation and ingestive behavior. Male rats were prepared with an electrode in the perifornical lateral hypothalamus and an ipsilateral guideshaft for microdialysis in the VTA. Extracellular ACh increased in the VTA during self-stimulation, auto-stimulation, eating, or drinking. Infusion of atropine into the VTA via the microdialysis probe was sufficient to stop self-stimulation and reduce intake of food. It is concluded that ACh acts at muscarinic receptors in the VTA as part of a circuit that modulates hypothalamic self-stimulation and ingestive behavior.}, author = {Rada, Pedro V. and Mark, Gregory P. and Yeomans, John J. and Hoebel, Bartley G. }, citeulike-article-id = {1597285}, doi = {10.1016/S0091-3057(99)00218-X}, journal = {Pharmacology Biochemistry and Behavior}, keywords = {acetylcholine, dopamine, reward}, month = {March}, number = {3}, pages = {375--379}, posted-at = {2007-08-27 21:23:34}, priority = {0}, title = {Acetylcholine Release in Ventral Tegmental Area by Hypothalamic Self-Stimulation, Eating, and Drinking}, url = {http://dx.doi.org/10.1016/S0091-3057(99)00218-X}, volume = {65}, year = {2000} }

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TY - JOUR ID - citeulike:1597285 L3 - citeulike-article-id:1597285 TI - Acetylcholine Release in Ventral Tegmental Area by Hypothalamic Self-Stimulation, Eating, and Drinking JF - Pharmacology Biochemistry and Behavior VL - 65 IS - 3 SP - 375 EP - 379 N2 - Evidence is presented for an acetylcholine (ACh) input to the midbrain ventral tegmental area (VTA) as part of a system for self-stimulation and ingestive behavior. Male rats were prepared with an electrode in the perifornical lateral hypothalamus and an ipsilateral guideshaft for microdialysis in the VTA. Extracellular ACh increased in the VTA during self-stimulation, auto-stimulation, eating, or drinking. Infusion of atropine into the VTA via the microdialysis probe was sufficient to stop self-stimulation and reduce intake of food. It is concluded that ACh acts at muscarinic receptors in the VTA as part of a circuit that modulates hypothalamic self-stimulation and ingestive behavior. KW - acetylcholine KW - dopamine KW - reward AU - Rada, Pedro AU - Mark, Gregory AU - Yeomans, John AU - Hoebel, Bartley PY - 2000/03// UR - http://dx.doi.org/10.1016/S0091-3057(99)00218-X ER -

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