The Hippocampal-VTA Loop: Controlling the Entry of Information into Long-Term Memory.

@article{citeulike:221022, abstract = {In this article we develop the concept that the hippocampus and the midbrain dopaminergic neurons of the ventral tegmental area (VTA) form a functional loop. Activation of the loop begins when the hippocampus detects newly arrived information that is not already stored in its long-term memory. The resulting novelty signal is conveyed through the subiculum, accumbens, and ventral pallidum to the VTA where it contributes (along with salience and goal information) to the novelty-dependent firing of these cells. In the upward arm of the loop, dopamine (DA) is released within the hippocampus; this produces an enhancement of LTP and learning. These findings support a model whereby the hippocampal-VTA loop regulates the entry of information into long-term memory.}, address = {Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454.}, author = {Lisman, J. E. and Grace, A. A. }, citeulike-article-id = {221022}, doi = {10.1016/j.neuron.2005.05.002}, issn = {0896-6273}, journal = {Neuron}, keywords = {dopamine, hippocampus, ltp, novelty, nucleus-accumbens, prefrontal-cortex, saliency, vta}, month = {June}, number = {5}, pages = {703--713}, posted-at = {2006-12-04 12:41:37}, priority = {0}, title = {The Hippocampal-VTA Loop: Controlling the Entry of Information into Long-Term Memory.}, url = {http://dx.doi.org/10.1016/j.neuron.2005.05.002}, volume = {46}, year = {2005} }

TY - JOUR ID - citeulike:221022 L3 - citeulike-article-id:221022 TI - The Hippocampal-VTA Loop: Controlling the Entry of Information into Long-Term Memory. JF - Neuron VL - 46 IS - 5 SP - 703 EP - 713 AD - Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454. SN - 0896-6273 N2 - In this article we develop the concept that the hippocampus and the midbrain dopaminergic neurons of the ventral tegmental area (VTA) form a functional loop. Activation of the loop begins when the hippocampus detects newly arrived information that is not already stored in its long-term memory. The resulting novelty signal is conveyed through the subiculum, accumbens, and ventral pallidum to the VTA where it contributes (along with salience and goal information) to the novelty-dependent firing of these cells. In the upward arm of the loop, dopamine (DA) is released within the hippocampus; this produces an enhancement of LTP and learning. These findings support a model whereby the hippocampal-VTA loop regulates the entry of information into long-term memory. KW - dopamine KW - hippocampus KW - ltp KW - novelty KW - nucleus-accumbens KW - prefrontal-cortex KW - saliency KW - vta AU - Lisman, JE AU - Grace, AA PY - 2005/06/02/ UR - http://dx.doi.org/10.1016/j.neuron.2005.05.002 ER -