Food Reward in the Absence of Taste Receptor Signaling

@article{citeulike:2615899, abstract = {Summary Food palatability and hedonic value play central roles in nutrient intake. However, postingestive effects can influence food preferences independently of palatability, although the neurobiological bases of such mechanisms remain poorly understood. Of central interest is whether the same brain reward circuitry that is responsive to palatable rewards also encodes metabolic value independently of taste signaling. Here we show that trpm5-/- mice, which lack the cellular machinery required for sweet taste transduction, can develop a robust preference for sucrose solutions based solely on caloric content. Sucrose intake induced dopamine release in the ventral striatum of these sweet-blind mice, a pattern usually associated with receipt of palatable rewards. Furthermore, single neurons in this same ventral striatal region showed increased sensitivity to caloric intake even in the absence of gustatory inputs. Our findings suggest that calorie-rich nutrients can directly influence brain reward circuits that control food intake independently of palatability or functional taste transduction.}, author = {de Araujo, Ivan E. and Oliveira-Maia, Albino J. and Sotnikova, Tatyana D. and Gainetdinov, Raul R. and Caron, Marc G. and Nicolelis, Miguel A. and Simon, Sidney A. }, citeulike-article-id = {2615899}, doi = {10.1016/j.neuron.2008.01.032}, journal = {Neuron}, keywords = {dopamine, reinforcement-learning, reward, taste}, month = {March}, number = {6}, pages = {930--941}, posted-at = {2008-03-31 12:11:55}, priority = {0}, title = {Food Reward in the Absence of Taste Receptor Signaling}, url = {http://dx.doi.org/10.1016/j.neuron.2008.01.032}, volume = {57}, year = {2008} }

TY - JOUR ID - citeulike:2615899 TI - Food Reward in the Absence of Taste Receptor Signaling JF - Neuron VL - 57 IS - 6 SP - 930 EP - 941 N2 - Summary Food palatability and hedonic value play central roles in nutrient intake. However, postingestive effects can influence food preferences independently of palatability, although the neurobiological bases of such mechanisms remain poorly understood. Of central interest is whether the same brain reward circuitry that is responsive to palatable rewards also encodes metabolic value independently of taste signaling. Here we show that trpm5-/- mice, which lack the cellular machinery required for sweet taste transduction, can develop a robust preference for sucrose solutions based solely on caloric content. Sucrose intake induced dopamine release in the ventral striatum of these sweet-blind mice, a pattern usually associated with receipt of palatable rewards. Furthermore, single neurons in this same ventral striatal region showed increased sensitivity to caloric intake even in the absence of gustatory inputs. Our findings suggest that calorie-rich nutrients can directly influence brain reward circuits that control food intake independently of palatability or functional taste transduction. KW - dopamine KW - reinforcement-learning KW - reward KW - taste AU - de Araujo, Ivan AU - Oliveira-Maia, Albino AU - Sotnikova, Tatyana AU - Gainetdinov, Raul AU - Caron, Marc AU - Nicolelis, Miguel AU - Simon, Sidney PY - 2008/03/27/ UR - http://dx.doi.org/10.1016/j.neuron.2008.01.032 ER -