Gain modulation from background synaptic input.

by: FS Chance, LF Abbott, AD Reyes

Neuron, Vol. 35, No. 4. (15 August 2002), pp. 773-782.

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Abstract

Gain modulation is a prominent feature of neuronal activity recorded in behaving animals, but the mechanism by which it occurs is unknown. By introducing a barrage of excitatory and inhibitory synaptic conductances that mimics conditions encountered in vivo into pyramidal neurons in slices of rat somatosensory cortex, we show that the gain of a neuronal response to excitatory drive can be modulated by varying the level of "background" synaptic input. Simultaneously increasing both excitatory and inhibitory background firing rates in a balanced manner results in a divisive gain modulation of the neuronal response without appreciable signal-independent increases in firing rate or spike-train variability. These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive.

@article{citeulike:419795, abstract = {Gain modulation is a prominent feature of neuronal activity recorded in behaving animals, but the mechanism by which it occurs is unknown. By introducing a barrage of excitatory and inhibitory synaptic conductances that mimics conditions encountered in vivo into pyramidal neurons in slices of rat somatosensory cortex, we show that the gain of a neuronal response to excitatory drive can be modulated by varying the level of "background" synaptic input. Simultaneously increasing both excitatory and inhibitory background firing rates in a balanced manner results in a divisive gain modulation of the neuronal response without appreciable signal-independent increases in firing rate or spike-train variability. These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive.}, address = {Center for Neural Science, New York University, New York, NY 10003, USA.}, author = {Chance, F. S. and Abbott, L. F. and Reyes, A. D. }, citeulike-article-id = {419795}, issn = {0896-6273}, journal = {Neuron}, keywords = {dynamic-clamp}, month = {August}, number = {4}, pages = {773--782}, posted-at = {2006-12-20 16:57:37}, priority = {1}, title = {Gain modulation from background synaptic input.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12194875}, volume = {35}, year = {2002} }

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TY - JOUR ID - citeulike:419795 L3 - citeulike-article-id:419795 TI - Gain modulation from background synaptic input. JF - Neuron VL - 35 IS - 4 SP - 773 EP - 782 AD - Center for Neural Science, New York University, New York, NY 10003, USA. SN - 0896-6273 N2 - Gain modulation is a prominent feature of neuronal activity recorded in behaving animals, but the mechanism by which it occurs is unknown. By introducing a barrage of excitatory and inhibitory synaptic conductances that mimics conditions encountered in vivo into pyramidal neurons in slices of rat somatosensory cortex, we show that the gain of a neuronal response to excitatory drive can be modulated by varying the level of "background" synaptic input. Simultaneously increasing both excitatory and inhibitory background firing rates in a balanced manner results in a divisive gain modulation of the neuronal response without appreciable signal-independent increases in firing rate or spike-train variability. These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive. KW - dynamic-clamp AU - Chance, FS AU - Abbott, LF AU - Reyes, AD PY - 2002/08/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12194875 ER -

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