Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans

by: Samuel R Chamberlain, Ulrich Muller, Andrew D Blackwell, Luke Clark, Trevor W Robbins, Barbara J Sahakian

Science, Vol. 311, No. 5762. (10 February 2006), pp. 861-863.

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Abstract

Cognitive functions dependent on the prefrontal cortex, such as the ability to suppress behavior (response inhibition) and to learn from complex feedback (probabilistic learning), play critical roles in activities of daily life. To what extent do different neurochemical systems modulate these two cognitive functions? Here, using stop-signal and probabilistic learning tasks, we show a double dissociation for the involvement of noradrenaline and serotonin in human cognition. In healthy volunteers, inhibition of central noradrenaline reuptake improved response inhibition but had no effect on probabilistic learning, whereas inhibition of central serotonin reuptake impaired probabilistic learning with no effect on response inhibition.

@article{citeulike:528362, abstract = {Cognitive functions dependent on the prefrontal cortex, such as the ability to suppress behavior (response inhibition) and to learn from complex feedback (probabilistic learning), play critical roles in activities of daily life. To what extent do different neurochemical systems modulate these two cognitive functions? Here, using stop-signal and probabilistic learning tasks, we show a double dissociation for the involvement of noradrenaline and serotonin in human cognition. In healthy volunteers, inhibition of central noradrenaline reuptake improved response inhibition but had no effect on probabilistic learning, whereas inhibition of central serotonin reuptake impaired probabilistic learning with no effect on response inhibition.}, author = {Chamberlain, Samuel R. and Muller, Ulrich and Blackwell, Andrew D. and Clark, Luke and Robbins, Trevor W. and Sahakian, Barbara J. }, citeulike-article-id = {528362}, doi = {http://dx.doi.org/10.1126/science.1121218}, journal = {Science}, month = {February}, number = {5762}, pages = {861--863}, posted-at = {2006-12-22 21:52:29}, priority = {2}, title = {Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans}, url = {http://dx.doi.org/10.1126/science.1121218}, volume = {311}, year = {2006} }

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TY - JOUR ID - citeulike:528362 L3 - citeulike-article-id:528362 TI - Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans JF - Science VL - 311 IS - 5762 SP - 861 EP - 863 N2 - Cognitive functions dependent on the prefrontal cortex, such as the ability to suppress behavior (response inhibition) and to learn from complex feedback (probabilistic learning), play critical roles in activities of daily life. To what extent do different neurochemical systems modulate these two cognitive functions? Here, using stop-signal and probabilistic learning tasks, we show a double dissociation for the involvement of noradrenaline and serotonin in human cognition. In healthy volunteers, inhibition of central noradrenaline reuptake improved response inhibition but had no effect on probabilistic learning, whereas inhibition of central serotonin reuptake impaired probabilistic learning with no effect on response inhibition. AU - Chamberlain, Samuel AU - Muller, Ulrich AU - Blackwell, Andrew AU - Clark, Luke AU - Robbins, Trevor AU - Sahakian, Barbara PY - 2006/02/10/ UR - http://dx.doi.org/10.1126/science.1121218 ER -

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