Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging.

@article{citeulike:576352, abstract = {Evidence concerning anatomical connectivities in the human brain is sparse and based largely on limited post-mortem observations. Diffusion tensor imaging has previously been used to define large white-matter tracts in the living human brain, but this technique has had limited success in tracing pathways into gray matter. Here we identified specific connections between human thalamus and cortex using a novel probabilistic tractography algorithm with diffusion imaging data. Classification of thalamic gray matter based on cortical connectivity patterns revealed distinct subregions whose locations correspond to nuclei described previously in histological studies. The connections that we found between thalamus and cortex were similar to those reported for non-human primates and were reproducible between individuals. Our results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.}, address = {Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.}, author = {Behrens, T. E. and Johansen-Berg, H. and Woolrich, M. W. and Smith, S. M. and Wheeler-Kingshott, C. A. and Boulby, P. A. and Barker, G. J. and Sillery, E. L. and Sheehan, K. and Ciccarelli, O. and Thompson, A. J. and Brady, J. M. and Matthews, P. M. }, citeulike-article-id = {576352}, doi = {10.1038/nn1075}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {connectivity, cortex, diffusion-tractography, prefrontal-cortex, thalamus}, month = {July}, number = {7}, pages = {750--757}, posted-at = {2007-05-16 16:55:16}, priority = {0}, title = {Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging.}, url = {http://dx.doi.org/10.1038/nn1075}, volume = {6}, year = {2003} }

TY - JOUR ID - citeulike:576352 L3 - citeulike-article-id:576352 TI - Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. JF - Nat Neurosci VL - 6 IS - 7 SP - 750 EP - 757 AD - Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. SN - 1097-6256 N2 - Evidence concerning anatomical connectivities in the human brain is sparse and based largely on limited post-mortem observations. Diffusion tensor imaging has previously been used to define large white-matter tracts in the living human brain, but this technique has had limited success in tracing pathways into gray matter. Here we identified specific connections between human thalamus and cortex using a novel probabilistic tractography algorithm with diffusion imaging data. Classification of thalamic gray matter based on cortical connectivity patterns revealed distinct subregions whose locations correspond to nuclei described previously in histological studies. The connections that we found between thalamus and cortex were similar to those reported for non-human primates and were reproducible between individuals. Our results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter. KW - connectivity KW - cortex KW - diffusion-tractography KW - prefrontal-cortex KW - thalamus AU - Behrens, TE AU - Johansen-Berg, H AU - Woolrich, MW AU - Smith, SM AU - Wheeler-Kingshott, CA AU - Boulby, PA AU - Barker, GJ AU - Sillery, EL AU - Sheehan, K AU - Ciccarelli, O AU - Thompson, AJ AU - Brady, JM AU - Matthews, PM PY - 2003/07// UR - http://dx.doi.org/10.1038/nn1075 ER -