Synaptic Theory of Working Memory

by: Gianluigi Mongillo, Omri Barak, Misha Tsodyks

Science, Vol. 319, No. 5869. (14 March 2008), pp. 1543-1546.

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Abstract

It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory. Here, we propose that working memory is sustained by calcium-mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a buffer that is loaded, refreshed, and read out by spiking activity. Because of the long time constants of calcium kinetics, the refresh rate can be low, resulting in a mechanism that is metabolically efficient and robust. The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network. 10.1126/science.1150769

@article{citeulike:2531838, abstract = {It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory. Here, we propose that working memory is sustained by calcium-mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a buffer that is loaded, refreshed, and read out by spiking activity. Because of the long time constants of calcium kinetics, the refresh rate can be low, resulting in a mechanism that is metabolically efficient and robust. The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network. 10.1126/science.1150769}, author = {Mongillo, Gianluigi and Barak, Omri and Tsodyks, Misha }, citeulike-article-id = {2531838}, doi = {10.1126/science.1150769}, journal = {Science}, keywords = {synapse}, month = {March}, number = {5869}, pages = {1543--1546}, posted-at = {2008-03-18 18:42:00}, priority = {2}, title = {Synaptic Theory of Working Memory}, url = {http://dx.doi.org/10.1126/science.1150769}, volume = {319}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2531838 L3 - citeulike-article-id:2531838 TI - Synaptic Theory of Working Memory JF - Science VL - 319 IS - 5869 SP - 1543 EP - 1546 N2 - It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory. Here, we propose that working memory is sustained by calcium-mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a buffer that is loaded, refreshed, and read out by spiking activity. Because of the long time constants of calcium kinetics, the refresh rate can be low, resulting in a mechanism that is metabolically efficient and robust. The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network. 10.1126/science.1150769 KW - synapse AU - Mongillo, Gianluigi AU - Barak, Omri AU - Tsodyks, Misha PY - 2008/03/14/ UR - http://dx.doi.org/10.1126/science.1150769 ER -

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