Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo.

@article{citeulike:2801522, abstract = {Understanding the function of complex cortical circuits requires the simultaneous recording of action potentials from many neurons in awake and behaving animals. Practically, this can be achieved by extracellularly recording from multiple brain sites using single wire electrodes. However, in densely packed neural structures such as the human hippocampus, a single electrode can record the activity of multiple neurons. Thus, analytic techniques that differentiate action potentials of different neurons are required. Offline spike sorting approaches are currently used to detect and sort action potentials after finishing the experiment. Because the opportunities to record from the human brain are relatively rare, it is desirable to analyze large numbers of simultaneous recordings quickly using online sorting and detection algorithms. In this way, the experiment can be optimized for the particular response properties of the recorded neurons. Here we present and evaluate a method that is capable of detecting and sorting extracellular single-wire recordings in realtime. We demonstrate the utility of the method by applying it to an extensive data set we acquired from chronically implanted depth electrodes in the hippocampus of human epilepsy patients. This dataset is particularly challenging because it was recorded in a noisy clinical environment. This method will allow the development of "closed-loop" experiments, which immediately adapt the experimental stimuli and/or tasks to the neural response observed.}, address = {Computation and Neural Systems, California Institute of Technology, Pasadena, 91125, USA.}, author = {Rutishauser, U. and Schuman, E. M. and Mamelak, A. N. }, citeulike-article-id = {2801522}, doi = {10.1016/j.jneumeth.2005.12.033}, issn = {0165-0270}, journal = {Journal of neuroscience methods}, keywords = {spikesorting}, month = {June}, number = {1-2}, pages = {204--224}, posted-at = {2008-05-15 13:37:54}, priority = {2}, title = {Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo.}, url = {http://dx.doi.org/10.1016/j.jneumeth.2005.12.033}, volume = {154}, year = {2006} }

TY - JOUR ID - citeulike:2801522 L3 - citeulike-article-id:2801522 TI - Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo. JF - Journal of neuroscience methods VL - 154 IS - 1-2 SP - 204 EP - 224 AD - Computation and Neural Systems, California Institute of Technology, Pasadena, 91125, USA. SN - 0165-0270 N2 - Understanding the function of complex cortical circuits requires the simultaneous recording of action potentials from many neurons in awake and behaving animals. Practically, this can be achieved by extracellularly recording from multiple brain sites using single wire electrodes. However, in densely packed neural structures such as the human hippocampus, a single electrode can record the activity of multiple neurons. Thus, analytic techniques that differentiate action potentials of different neurons are required. Offline spike sorting approaches are currently used to detect and sort action potentials after finishing the experiment. Because the opportunities to record from the human brain are relatively rare, it is desirable to analyze large numbers of simultaneous recordings quickly using online sorting and detection algorithms. In this way, the experiment can be optimized for the particular response properties of the recorded neurons. Here we present and evaluate a method that is capable of detecting and sorting extracellular single-wire recordings in realtime. We demonstrate the utility of the method by applying it to an extensive data set we acquired from chronically implanted depth electrodes in the hippocampus of human epilepsy patients. This dataset is particularly challenging because it was recorded in a noisy clinical environment. This method will allow the development of "closed-loop" experiments, which immediately adapt the experimental stimuli and/or tasks to the neural response observed. KW - spikesorting AU - Rutishauser, U AU - Schuman, EM AU - Mamelak, AN PY - 2006/06/30/ UR - http://dx.doi.org/10.1016/j.jneumeth.2005.12.033 ER -