Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle.

by: KG Le Roch, JR Johnson, L Florens, Y Zhou, A Santrosyan, M Grainger, SF Yan, KC Williamson, AA Holder, DJ Carucci, JR Yates, EA Winzeler

Genome Res, Vol. 14, No. 11. (November 2004), pp. 2308-2318.

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Abstract

To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for these stages; the most common discrepancy was a delay between mRNA and protein accumulation. Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.

@article{citeulike:841191, abstract = {To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for these stages; the most common discrepancy was a delay between mRNA and protein accumulation. Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.}, address = {Department of Cell Biology ICND202, the Scripps Research Institute, La Jolla, California 92037, USA.}, author = {Le Roch, K. G. and Johnson, J. R. and Florens, L. and Zhou, Y. and Santrosyan, A. and Grainger, M. and Yan, S. F. and Williamson, K. C. and Holder, A. A. and Carucci, D. J. and Yates, J. R. and Winzeler, E. A. }, citeulike-article-id = {841191}, doi = {http://dx.doi.org/10.1101/gr.2523904}, issn = {1088-9051}, journal = {Genome Res}, keywords = {gene-reg, omics}, month = {November}, number = {11}, pages = {2308--2318}, posted-at = {2006-10-20 16:58:21}, priority = {2}, title = {Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle.}, url = {http://dx.doi.org/10.1101/gr.2523904}, volume = {14}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:841191 L3 - citeulike-article-id:841191 TI - Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. JF - Genome Res VL - 14 IS - 11 SP - 2308 EP - 2318 AD - Department of Cell Biology ICND202, the Scripps Research Institute, La Jolla, California 92037, USA. SN - 1088-9051 N2 - To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for these stages; the most common discrepancy was a delay between mRNA and protein accumulation. Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation. KW - gene-reg KW - omics AU - Le Roch, KG AU - Johnson, JR AU - Florens, L AU - Zhou, Y AU - Santrosyan, A AU - Grainger, M AU - Yan, SF AU - Williamson, KC AU - Holder, AA AU - Carucci, DJ AU - Yates, JR AU - Winzeler, EA PY - 2004/11// UR - http://dx.doi.org/10.1101/gr.2523904 ER -

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