Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes.

@article{citeulike:2800529, abstract = {In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract the glucose uptake suppression caused by tumor necrosis factor alpha in 3T3-L1 adipocytes. The mechanism dissection showed that the IL-18 upregulated phosphorylated Akt and downregulated phosphorylated P38 MAPK. These findings indicated that the elevated serum IL-18 levels in obesity and diabetes might be a compensatory response to insulin resistance.}, address = {Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine \& Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University Medical School, 197 Rui-Jin 2nd Road, Shanghai, 200025, China.}, author = {Yang, Yi-Sheng S. and Li, Xiao-Ying Y. and Hong, Jie and Gu, Wei-Qiong Q. and Zhang, Yi-Fei F. and Yang, Jun and Song, Huai-Dong D. and Chen, Jia-Lun L. and Ning, Guang }, citeulike-article-id = {2800529}, doi = {10.1007/s12020-008-9048-z}, issn = {0969-711X}, journal = {Endocrine}, keywords = {il-18}, month = {December}, number = {3}, pages = {297--302}, posted-at = {2008-05-15 03:30:36}, priority = {2}, title = {Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes.}, url = {http://dx.doi.org/10.1007/s12020-008-9048-z}, volume = {32}, year = {2007} }

TY - JOUR ID - citeulike:2800529 L3 - citeulike-article-id:2800529 TI - Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes. JF - Endocrine VL - 32 IS - 3 SP - 297 EP - 302 AD - Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine & Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University Medical School, 197 Rui-Jin 2nd Road, Shanghai, 200025, China. SN - 0969-711X N2 - In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract the glucose uptake suppression caused by tumor necrosis factor alpha in 3T3-L1 adipocytes. The mechanism dissection showed that the IL-18 upregulated phosphorylated Akt and downregulated phosphorylated P38 MAPK. These findings indicated that the elevated serum IL-18 levels in obesity and diabetes might be a compensatory response to insulin resistance. KW - il-18 AU - Yang, Yi-Sheng AU - Li, Xiao-Ying AU - Hong, Jie AU - Gu, Wei-Qiong AU - Zhang, Yi-Fei AU - Yang, Jun AU - Song, Huai-Dong AU - Chen, Jia-Lun AU - Ning, Guang PY - 2007/12// UR - http://dx.doi.org/10.1007/s12020-008-9048-z ER -