Operant reward learning in Aplysia: neuronal correlates and mechanisms.

by: B Brembs, FD Lorenzetti, FD Reyes, DA Baxter, JH Byrne

Science, Vol. 296, No. 5573. (31 May 2002), pp. 1706-1709.

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Abstract

Operant conditioning is a form of associative learning through which an animal learns about the consequences of its behavior. Here, we report an appetitive operant conditioning procedure in Aplysia that induces long-term memory. Biophysical changes that accompanied the memory were found in an identified neuron (cell B51) that is considered critical for the expression of behavior that was rewarded. Similar cellular changes in B51 were produced by contingent reinforcement of B51 with dopamine in a single-cell analog of the operant procedure. These findings allow for the detailed analysis of the cellular and molecular processes underlying operant conditioning.

@article{citeulike:877189, abstract = {Operant conditioning is a form of associative learning through which an animal learns about the consequences of its behavior. Here, we report an appetitive operant conditioning procedure in Aplysia that induces long-term memory. Biophysical changes that accompanied the memory were found in an identified neuron (cell B51) that is considered critical for the expression of behavior that was rewarded. Similar cellular changes in B51 were produced by contingent reinforcement of B51 with dopamine in a single-cell analog of the operant procedure. These findings allow for the detailed analysis of the cellular and molecular processes underlying operant conditioning.}, address = {Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas-Houston Medical School, Houston, TX 77030, USA.}, author = {Brembs, B. and Lorenzetti, F. D. and Reyes, F. D. and Baxter, D. A. and Byrne, J. H. }, citeulike-article-id = {877189}, doi = {10.1126/science.1069434}, issn = {1095-9203}, journal = {Science}, keywords = {aplysia, conditioning, learning, memory, neurobiology, neuroscience, operant, physiology, slug, snail}, month = {May}, number = {5573}, pages = {1706--1709}, posted-at = {2006-09-29 08:02:24}, priority = {0}, title = {Operant reward learning in Aplysia: neuronal correlates and mechanisms.}, url = {http://dx.doi.org/10.1126/science.1069434}, volume = {296}, year = {2002} }

RIS record

TY - JOUR ID - citeulike:877189 L3 - citeulike-article-id:877189 TI - Operant reward learning in Aplysia: neuronal correlates and mechanisms. JF - Science VL - 296 IS - 5573 SP - 1706 EP - 1709 AD - Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas-Houston Medical School, Houston, TX 77030, USA. SN - 1095-9203 N2 - Operant conditioning is a form of associative learning through which an animal learns about the consequences of its behavior. Here, we report an appetitive operant conditioning procedure in Aplysia that induces long-term memory. Biophysical changes that accompanied the memory were found in an identified neuron (cell B51) that is considered critical for the expression of behavior that was rewarded. Similar cellular changes in B51 were produced by contingent reinforcement of B51 with dopamine in a single-cell analog of the operant procedure. These findings allow for the detailed analysis of the cellular and molecular processes underlying operant conditioning. KW - aplysia KW - conditioning KW - learning KW - memory KW - neurobiology KW - neuroscience KW - operant KW - physiology KW - slug KW - snail AU - Brembs, B AU - Lorenzetti, FD AU - Reyes, FD AU - Baxter, DA AU - Byrne, JH PY - 2002/05/31/ UR - http://dx.doi.org/10.1126/science.1069434 ER -

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