PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.

by: RJ Chan, GS Feng

Blood, Vol. 109, No. 3. (1 February 2007), pp. 862-867.

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Abstract

Elucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and characterization of oncogenes and tumor suppressor genes. One new advance in this field is the identification of PTPN11 as the first proto-oncogene that encodes a cytoplasmic tyrosine phosphatase with 2 Src-homology 2 (SH2) domains (Shp2). This tyrosine phosphatase was previously shown to play an essential role in normal hematopoiesis. More recently, somatic missense PTPN11 gain-of-function mutations have been detected in leukemias and rarely in solid tumors, and have been found to induce aberrant hyperactivation of the Ras-Erk pathway. This progress represents another milestone in the leukemia/cancer research field and provides a fresh view on the molecular mechanisms underlying cell transformation.

@article{citeulike:2739308, abstract = {Elucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and characterization of oncogenes and tumor suppressor genes. One new advance in this field is the identification of PTPN11 as the first proto-oncogene that encodes a cytoplasmic tyrosine phosphatase with 2 Src-homology 2 (SH2) domains (Shp2). This tyrosine phosphatase was previously shown to play an essential role in normal hematopoiesis. More recently, somatic missense PTPN11 gain-of-function mutations have been detected in leukemias and rarely in solid tumors, and have been found to induce aberrant hyperactivation of the Ras-Erk pathway. This progress represents another milestone in the leukemia/cancer research field and provides a fresh view on the molecular mechanisms underlying cell transformation.}, address = {Department of Pediatrics, the Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA.}, author = {Chan, R. J. and Feng, G. S. }, citeulike-article-id = {2739308}, doi = {10.1182/blood-2006-07-028829}, issn = {0006-4971}, journal = {Blood}, keywords = {shp2}, month = {February}, number = {3}, pages = {862--867}, posted-at = {2008-04-30 18:46:40}, priority = {2}, title = {PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.}, url = {http://dx.doi.org/10.1182/blood-2006-07-028829}, volume = {109}, year = {2007} }

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TY - JOUR ID - citeulike:2739308 L3 - citeulike-article-id:2739308 TI - PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. JF - Blood VL - 109 IS - 3 SP - 862 EP - 867 AD - Department of Pediatrics, the Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA. SN - 0006-4971 N2 - Elucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and characterization of oncogenes and tumor suppressor genes. One new advance in this field is the identification of PTPN11 as the first proto-oncogene that encodes a cytoplasmic tyrosine phosphatase with 2 Src-homology 2 (SH2) domains (Shp2). This tyrosine phosphatase was previously shown to play an essential role in normal hematopoiesis. More recently, somatic missense PTPN11 gain-of-function mutations have been detected in leukemias and rarely in solid tumors, and have been found to induce aberrant hyperactivation of the Ras-Erk pathway. This progress represents another milestone in the leukemia/cancer research field and provides a fresh view on the molecular mechanisms underlying cell transformation. KW - shp2 AU - Chan, RJ AU - Feng, GS PY - 2007/02/01/ UR - http://dx.doi.org/10.1182/blood-2006-07-028829 ER -

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