Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans.

@article{citeulike:1403448, abstract = {In C. elegans, Wnt signaling regulates a number of asymmetric cell divisions. During telophase, WRM-1/beta-catenin localizes asymmetrically to the anterior cortex and the posterior daughter's nucleus. However, cortical WRM-1's functions are not known. Here, we use a membrane-targeted form of WRM-1 to show that cortical WRM-1 inhibits Wnt signaling and the nuclear localization of WRM-1. These functions are mediated by APR-1/APC, which regulates WRM-1 nuclear export. We also show that APR-1 as well as PRY-1/Axin and Dishevelled homologs localize asymmetrically to the cortex. Our results suggest a model in which cortical WRM-1 recruits APR-1 to the anterior cortex before and during division, and the cortical APR-1 stimulates WRM-1 export from the anterior nucleus at telophase. Because beta-catenin and APC are localized to the cortex in many cell types in different species, our results suggest that these cortical proteins may regulate asymmetric divisions or Wnt signaling in other organisms as well.}, address = {Laboratory for Cell Fate Decision, Riken, Center for Developmental Biology, Kobe 650-0047, Japan.}, author = {Mizumoto, K. and Sawa, H. }, citeulike-article-id = {1403448}, doi = {10.1016/j.devcel.2007.01.004}, issn = {1534-5807}, journal = {Dev Cell}, keywords = {b-catenin, differentiation}, month = {February}, number = {2}, pages = {287--299}, posted-at = {2007-06-21 23:33:20}, priority = {2}, title = {Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans.}, url = {http://dx.doi.org/10.1016/j.devcel.2007.01.004}, volume = {12}, year = {2007} }

TY - JOUR ID - citeulike:1403448 L3 - citeulike-article-id:1403448 TI - Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans. JF - Dev Cell VL - 12 IS - 2 SP - 287 EP - 299 AD - Laboratory for Cell Fate Decision, Riken, Center for Developmental Biology, Kobe 650-0047, Japan. SN - 1534-5807 N2 - In C. elegans, Wnt signaling regulates a number of asymmetric cell divisions. During telophase, WRM-1/beta-catenin localizes asymmetrically to the anterior cortex and the posterior daughter's nucleus. However, cortical WRM-1's functions are not known. Here, we use a membrane-targeted form of WRM-1 to show that cortical WRM-1 inhibits Wnt signaling and the nuclear localization of WRM-1. These functions are mediated by APR-1/APC, which regulates WRM-1 nuclear export. We also show that APR-1 as well as PRY-1/Axin and Dishevelled homologs localize asymmetrically to the cortex. Our results suggest a model in which cortical WRM-1 recruits APR-1 to the anterior cortex before and during division, and the cortical APR-1 stimulates WRM-1 export from the anterior nucleus at telophase. Because beta-catenin and APC are localized to the cortex in many cell types in different species, our results suggest that these cortical proteins may regulate asymmetric divisions or Wnt signaling in other organisms as well. KW - b-catenin KW - differentiation AU - Mizumoto, K AU - Sawa, H PY - 2007/02// UR - http://dx.doi.org/10.1016/j.devcel.2007.01.004 ER -