Electric Fields Due to Synaptic Currents Sharpen Excitatory Transmission

by: Sergiy Sylantyev, Leonid P Savtchenko, Yin-Ping Niu, Anton I Ivanov, Thomas P Jensen, Dimitri M Kullmann, Min-Yi Xiao, Dmitri A Rusakov

Science, Vol. 319, No. 5871. (28 March 2008), pp. 1845-1849.

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080408, 2pe, 2-photon, ampa, ampa_receptors, biophysics, cleft, depolarization, diffusion, e_fields, electrodiffusion, gaba, glutamate, integration, lab_meeting, neurotransmitter, outside-out, signal, synapse, synaptic_transmission, voltage

Abstract

The synaptic response waveform, which determines signal integration properties in the brain, depends on the spatiotemporal profile of neurotransmitter in the synaptic cleft. Here, we show that electrophoretic interactions between AMPA receptormediated excitatory currents and negatively charged glutamate molecules accelerate the clearance of glutamate from the synaptic cleft, speeding up synaptic responses. This phenomenon is reversed upon depolarization and diminished when intracleft electric fields are weakened through a decrease in the AMPA receptor density. In contrast, the kinetics of receptor-mediated currents evoked by direct application of glutamate are voltage-independent, as are synaptic currents mediated by the electrically neutral neurotransmitter GABA. Voltage-dependent temporal tuning of excitatory synaptic responses may thus contribute to signal integration in neural circuits. 10.1126/science.1154330

@article{citeulike:2605805, abstract = {The synaptic response waveform, which determines signal integration properties in the brain, depends on the spatiotemporal profile of neurotransmitter in the synaptic cleft. Here, we show that electrophoretic interactions between AMPA receptormediated excitatory currents and negatively charged glutamate molecules accelerate the clearance of glutamate from the synaptic cleft, speeding up synaptic responses. This phenomenon is reversed upon depolarization and diminished when intracleft electric fields are weakened through a decrease in the AMPA receptor density. In contrast, the kinetics of receptor-mediated currents evoked by direct application of glutamate are voltage-independent, as are synaptic currents mediated by the electrically neutral neurotransmitter GABA. Voltage-dependent temporal tuning of excitatory synaptic responses may thus contribute to signal integration in neural circuits. 10.1126/science.1154330}, author = {Sylantyev, Sergiy and Savtchenko, Leonid P. and Niu, Yin-Ping and Ivanov, Anton I. and Jensen, Thomas P. and Kullmann, Dimitri M. and Xiao, Min-Yi and Rusakov, Dmitri A. }, citeulike-article-id = {2605805}, doi = {10.1126/science.1154330}, journal = {Science}, keywords = {cleft, depolarization, gaba, glutamate, neurotransmitter, signal, synapse, voltage}, month = {March}, number = {5871}, pages = {1845--1849}, posted-at = {2008-04-18 16:13:35}, priority = {2}, title = {Electric Fields Due to Synaptic Currents Sharpen Excitatory Transmission}, url = {http://dx.doi.org/10.1126/science.1154330}, volume = {319}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2605805 L3 - citeulike-article-id:2605805 TI - Electric Fields Due to Synaptic Currents Sharpen Excitatory Transmission JF - Science VL - 319 IS - 5871 SP - 1845 EP - 1849 N2 - The synaptic response waveform, which determines signal integration properties in the brain, depends on the spatiotemporal profile of neurotransmitter in the synaptic cleft. Here, we show that electrophoretic interactions between AMPA receptormediated excitatory currents and negatively charged glutamate molecules accelerate the clearance of glutamate from the synaptic cleft, speeding up synaptic responses. This phenomenon is reversed upon depolarization and diminished when intracleft electric fields are weakened through a decrease in the AMPA receptor density. In contrast, the kinetics of receptor-mediated currents evoked by direct application of glutamate are voltage-independent, as are synaptic currents mediated by the electrically neutral neurotransmitter GABA. Voltage-dependent temporal tuning of excitatory synaptic responses may thus contribute to signal integration in neural circuits. 10.1126/science.1154330 KW - cleft KW - depolarization KW - gaba KW - glutamate KW - neurotransmitter KW - signal KW - synapse KW - voltage AU - Sylantyev, Sergiy AU - Savtchenko, Leonid AU - Niu, Yin-Ping AU - Ivanov, Anton AU - Jensen, Thomas AU - Kullmann, Dimitri AU - Xiao, Min-Yi AU - Rusakov, Dmitri PY - 2008/03/28/ UR - http://dx.doi.org/10.1126/science.1154330 ER -

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