Self-Assembled Polymer Membrane Capsules Inflated by Osmotic Pressure

@article{citeulike:2710303, abstract = {Abstract: We fabricate and characterize capsules that are composite membranes, made of a polymer network stabilized by adsorption to colloids and inflated by osmotic pressure from internal free polyelectrolyte; here, poly-L-lysine forms the network and inflates the capsules. To assess these capsules' properties and structure, we deform capsules using microcantilevers and use finite element modeling to describe these deformations. Additional experimental tests confirm the model's validity. These capsules' resilient response to mechanical forces indicates that loading and shear should be good triggers for the release of contents via deformation. The osmotic pressure inflating these capsules has the potential to trigger release of contents via deflation in response to changes in the capsules' environment; we demonstrate addition of salt as a trigger for deflating capsules. Because these capsules have a variety of release triggers available and the technique used to fabricate them is very flexible and allows high encapsulation efficiency, these capsules have very high potential for application in many areas.}, address = {Contribution from the Department of Physics and Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, Lehrstuhl fuer Biophysik - E22, Technische Universitaet Muenchen, Germany, Los Alamos National Laboratory, Chemistry Division, Los Alamos, New Mexico 87545, and The Nanotechnology Lab, Kraft Foods R\&D, 801 Waukegan Road, Glenview, Illinois 60025}, author = {Gordon, V. D. and Chen, X. and Hutchinson, J. W. and Bausch, A. R. and Marquez, M. and Weitz, D. A. }, citeulike-article-id = {2710303}, doi = {10.1021/ja0474749}, journal = {J. Am. Chem. Soc.}, keywords = {emulsion, technique, weitz}, month = {November}, number = {43}, pages = {14117--14122}, posted-at = {2008-04-23 22:59:32}, priority = {2}, title = {Self-Assembled Polymer Membrane Capsules Inflated by Osmotic Pressure}, url = {http://dx.doi.org/10.1021/ja0474749}, volume = {126}, year = {2004} }

TY - JOUR ID - citeulike:2710303 L3 - citeulike-article-id:2710303 TI - Self-Assembled Polymer Membrane Capsules Inflated by Osmotic Pressure JF - J. Am. Chem. Soc. VL - 126 IS - 43 SP - 14117 EP - 14122 AD - Contribution from the Department of Physics and Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, Lehrstuhl fuer Biophysik - E22, Technische Universitaet Muenchen, Germany, Los Alamos National Laboratory, Chemistry Division, Los Alamos, New Mexico 87545, and The Nanotechnology Lab, Kraft Foods R&D, 801 Waukegan Road, Glenview, Illinois 60025 N2 - Abstract: We fabricate and characterize capsules that are composite membranes, made of a polymer network stabilized by adsorption to colloids and inflated by osmotic pressure from internal free polyelectrolyte; here, poly-L-lysine forms the network and inflates the capsules. To assess these capsules' properties and structure, we deform capsules using microcantilevers and use finite element modeling to describe these deformations. Additional experimental tests confirm the model's validity. These capsules' resilient response to mechanical forces indicates that loading and shear should be good triggers for the release of contents via deformation. The osmotic pressure inflating these capsules has the potential to trigger release of contents via deflation in response to changes in the capsules' environment; we demonstrate addition of salt as a trigger for deflating capsules. Because these capsules have a variety of release triggers available and the technique used to fabricate them is very flexible and allows high encapsulation efficiency, these capsules have very high potential for application in many areas. KW - emulsion KW - technique KW - weitz AU - Gordon, VD AU - Chen, X AU - Hutchinson, JW AU - Bausch, AR AU - Marquez, M AU - Weitz, DA PY - 2004/11/03/ UR - http://dx.doi.org/10.1021/ja0474749 ER -