Proteins: Coexistence of Stability and Flexibility

by: Shlomi Reuveni, Rony Granek, Joseph Klafter

Physical Review Letters, Vol. 100, No. 20. (2008)

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Abstract

We introduce an equation for protein native topology based on recent analysis of data from the Protein Data Bank and on a generalization of the Landau-Peierls instability criterion for fractals. The equation relates the protein fractal dimension df, the spectral dimension ds, and the number of amino acids N. Deviations from the equation may render a protein unfolded. The fractal nature of proteins is shown to bridge their seemingly conflicting properties of stability and flexibility. Over 500 proteins have been analyzed (df, ds, and N) and found to obey this equation of state.

@article{citeulike:2870176, abstract = {We introduce an equation for protein native topology based on recent analysis of data from the Protein Data Bank and on a generalization of the Landau-Peierls instability criterion for fractals. The equation relates the protein fractal dimension df, the spectral dimension ds, and the number of amino acids N. Deviations from the equation may render a protein unfolded. The fractal nature of proteins is shown to bridge their seemingly conflicting properties of stability and flexibility. Over 500 proteins have been analyzed (df, ds, and N) and found to obey this equation of state.}, author = {Reuveni, Shlomi and Granek, Rony and Klafter, Joseph }, citeulike-article-id = {2870176}, doi = {http://dx.doi.org/10.1103/PhysRevLett.100.208101}, journal = {Physical Review Letters}, keywords = {2008, biology, modulus, protein, shear, theory}, number = {20}, posted-at = {2008-06-06 19:13:04}, priority = {2}, publisher = {APS}, title = {Proteins: Coexistence of Stability and Flexibility}, url = {http://dx.doi.org/10.1103/PhysRevLett.100.208101}, volume = {100}, year = {2008} }

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TY - JOUR ID - citeulike:2870176 L3 - citeulike-article-id:2870176 TI - Proteins: Coexistence of Stability and Flexibility JF - Physical Review Letters VL - 100 IS - 20 PB - APS N2 - We introduce an equation for protein native topology based on recent analysis of data from the Protein Data Bank and on a generalization of the Landau-Peierls instability criterion for fractals. The equation relates the protein fractal dimension df, the spectral dimension ds, and the number of amino acids N. Deviations from the equation may render a protein unfolded. The fractal nature of proteins is shown to bridge their seemingly conflicting properties of stability and flexibility. Over 500 proteins have been analyzed (df, ds, and N) and found to obey this equation of state. KW - 2008 KW - biology KW - modulus KW - protein KW - shear KW - theory AU - Reuveni, Shlomi AU - Granek, Rony AU - Klafter, Joseph PY - 2008/// UR - http://dx.doi.org/10.1103/PhysRevLett.100.208101 ER -

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