Human Genome Ultraconserved Elements Are Ultraselected

by: Sol Katzman, Andrew D Kern, Gill Bejerano, Ginger Fewell, Lucinda Fulton, Richard K Wilson, Sofie R Salama, David Haussler

Science, Vol. 317, No. 5840. (17 August 2007), 915.

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Abstract

Ultraconserved elements in the human genome are defined as stretches of at least 200 base pairs of DNA that match identically with corresponding regions in the mouse and rat genomes. Most ultraconserved elements are noncoding and have been evolutionarily conserved since mammal and bird ancestors diverged over 300 million years ago. The reason for this extreme conservation remains a mystery. It has been speculated that they are mutational cold spots or regions where every site is under weak but still detectable negative selection. However, analysis of the derived allele frequency spectrum shows that these regions are in fact under negative selection that is much stronger than that in protein coding genes. 10.1126/science.1142430

@article{citeulike:1577034, abstract = {Ultraconserved elements in the human genome are defined as stretches of at least 200 base pairs of DNA that match identically with corresponding regions in the mouse and rat genomes. Most ultraconserved elements are noncoding and have been evolutionarily conserved since mammal and bird ancestors diverged over 300 million years ago. The reason for this extreme conservation remains a mystery. It has been speculated that they are mutational cold spots or regions where every site is under weak but still detectable negative selection. However, analysis of the derived allele frequency spectrum shows that these regions are in fact under negative selection that is much stronger than that in protein coding genes. 10.1126/science.1142430}, author = {Katzman, Sol and Kern, Andrew D. and Bejerano, Gill and Fewell, Ginger and Fulton, Lucinda and Wilson, Richard K. and Salama, Sofie R. and Haussler, David }, citeulike-article-id = {1577034}, doi = {http://dx.doi.org/10.1126/science.1142430}, journal = {Science}, keywords = {conservation, selection}, month = {August}, number = {5840}, pages = {915+}, posted-at = {2007-08-20 16:42:57}, priority = {3}, title = {Human Genome Ultraconserved Elements Are Ultraselected}, url = {http://dx.doi.org/10.1126/science.1142430}, volume = {317}, year = {2007} }

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TY - JOUR ID - citeulike:1577034 L3 - citeulike-article-id:1577034 TI - Human Genome Ultraconserved Elements Are Ultraselected JF - Science VL - 317 IS - 5840 SP - 915 N2 - Ultraconserved elements in the human genome are defined as stretches of at least 200 base pairs of DNA that match identically with corresponding regions in the mouse and rat genomes. Most ultraconserved elements are noncoding and have been evolutionarily conserved since mammal and bird ancestors diverged over 300 million years ago. The reason for this extreme conservation remains a mystery. It has been speculated that they are mutational cold spots or regions where every site is under weak but still detectable negative selection. However, analysis of the derived allele frequency spectrum shows that these regions are in fact under negative selection that is much stronger than that in protein coding genes. 10.1126/science.1142430 KW - conservation KW - selection AU - Katzman, Sol AU - Kern, Andrew AU - Bejerano, Gill AU - Fewell, Ginger AU - Fulton, Lucinda AU - Wilson, Richard AU - Salama, Sofie AU - Haussler, David PY - 2007/08/17/ UR - http://dx.doi.org/10.1126/science.1142430 ER -

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