Tuning in to the signals: noncoding sequence conservation in vertebrate genomes

by: Greg Elgar, Tanya Vavouri

Trends in Genetics, Vol. In Press, Corrected Proof

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Abstract

Aligning and comparing genomic sequences enables the identification of conserved sequence signatures and can enrich for coding and noncoding functional regions. In vertebrates, the comparison of human and rodent genomes and the comparison of evolutionarily distant genomes, such as human and pufferfish, have identified specific sets of [`]ultraconserved' sequence elements associated with the control of early development. However, is this just the tip of a [`]conservation iceberg' or do these sequences represent a specific class of regulatory element? Studies on the zebrafish phox2b gene region and the ENCODE project suggest that many regulatory elements are not highly conserved, posing intriguing questions about the relationship between noncoding sequence conservation and function and the evolution of regulatory sequences.

@article{citeulike:2909268, abstract = {Aligning and comparing genomic sequences enables the identification of conserved sequence signatures and can enrich for coding and noncoding functional regions. In vertebrates, the comparison of human and rodent genomes and the comparison of evolutionarily distant genomes, such as human and pufferfish, have identified specific sets of [`]ultraconserved' sequence elements associated with the control of early development. However, is this just the tip of a [`]conservation iceberg' or do these sequences represent a specific class of regulatory element? Studies on the zebrafish phox2b gene region and the ENCODE project suggest that many regulatory elements are not highly conserved, posing intriguing questions about the relationship between noncoding sequence conservation and function and the evolution of regulatory sequences.}, author = {Elgar, Greg and Vavouri, Tanya }, citeulike-article-id = {2909268}, doi = {http://dx.doi.org/10.1016/j.tig.2008.04.005}, journal = {Trends in Genetics}, keywords = {conservation}, posted-at = {2008-06-22 18:10:45}, priority = {2}, title = {Tuning in to the signals: noncoding sequence conservation in vertebrate genomes}, url = {http://dx.doi.org/10.1016/j.tig.2008.04.005}, volume = {In Press, Corrected Proof} }

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TY - JOUR ID - citeulike:2909268 L3 - citeulike-article-id:2909268 TI - Tuning in to the signals: noncoding sequence conservation in vertebrate genomes JF - Trends in Genetics VL - In Press, Corrected Proof N2 - Aligning and comparing genomic sequences enables the identification of conserved sequence signatures and can enrich for coding and noncoding functional regions. In vertebrates, the comparison of human and rodent genomes and the comparison of evolutionarily distant genomes, such as human and pufferfish, have identified specific sets of [`]ultraconserved' sequence elements associated with the control of early development. However, is this just the tip of a [`]conservation iceberg' or do these sequences represent a specific class of regulatory element? Studies on the zebrafish phox2b gene region and the ENCODE project suggest that many regulatory elements are not highly conserved, posing intriguing questions about the relationship between noncoding sequence conservation and function and the evolution of regulatory sequences. KW - conservation AU - Elgar, Greg AU - Vavouri, Tanya UR - http://dx.doi.org/10.1016/j.tig.2008.04.005 ER -

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