Computation and Analysis of Genomis Multi-Sequence Alignments.

@article{citeulike:1320130, abstract = {Multi-sequence alignments of large genomic regions are at the core of many computational genome-annotation approaches aimed at identifying coding regions, RNA genes, regulatory regions, and other functional features. Such alignments also underlie many genome-evolution studies. Here we review recent computational advances in the area of multi-sequence alignment, focusing on methods suitable for aligning whole vertebrate genomes. We introduce the key algorithmic ideas in use today, and identify publicly available resources for computing, accessing, and visualizing genomic alignments. Finally, we describe the latest alignment-based approaches to identify and characterize various types of functional sequences. Key areas of research are identified and directions for future improvements are suggested. Expected final online publication date for the Annual Review of Genomics and Human Genetics Volume 8 is August 30, 2007. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.}, address = {McGill Centre for Bioinformatics, McGill University, Montreal, Quebec H3A 2B4 Canada blanchem@mcb.mcgill.ca.}, author = {Blanchette, Mathieu }, citeulike-article-id = {1320130}, doi = {http://dx.doi.org/10.1146/annurev.genom.8.080706.092300}, issn = {1527-8204}, journal = {Annu Rev Genomics Hum Genet}, keywords = {comparative\_genomics, multiple\_alignment}, month = {May}, posted-at = {2007-05-23 00:24:26}, priority = {3}, title = {Computation and Analysis of Genomis Multi-Sequence Alignments.}, url = {http://dx.doi.org/10.1146/annurev.genom.8.080706.092300}, year = {2007} }

TY - JOUR ID - citeulike:1320130 L3 - citeulike-article-id:1320130 TI - Computation and Analysis of Genomis Multi-Sequence Alignments. JF - Annu Rev Genomics Hum Genet AD - McGill Centre for Bioinformatics, McGill University, Montreal, Quebec H3A 2B4 Canada blanchem@mcb.mcgill.ca. SN - 1527-8204 N2 - Multi-sequence alignments of large genomic regions are at the core of many computational genome-annotation approaches aimed at identifying coding regions, RNA genes, regulatory regions, and other functional features. Such alignments also underlie many genome-evolution studies. Here we review recent computational advances in the area of multi-sequence alignment, focusing on methods suitable for aligning whole vertebrate genomes. We introduce the key algorithmic ideas in use today, and identify publicly available resources for computing, accessing, and visualizing genomic alignments. Finally, we describe the latest alignment-based approaches to identify and characterize various types of functional sequences. Key areas of research are identified and directions for future improvements are suggested. Expected final online publication date for the Annual Review of Genomics and Human Genetics Volume 8 is August 30, 2007. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. KW - comparative_genomics KW - multiple_alignment AU - Blanchette, Mathieu PY - 2007/05/09/ UR - http://dx.doi.org/10.1146/annurev.genom.8.080706.092300 ER -