GORouter: an RDF model for providing semantic query and inference services for Gene Ontology and its associations

@article{citeulike:2587504, abstract = {BACKGROUND:The most renowned biological ontology, Gene Ontology (GO) is widely used for annotations of genes and gene products of different organisms. However, there are shortcomings in the Resource Description Framework (RDF) data file provided by the GO consortium: 1) Lack of sufficient semantic relationships between pairs of terms coming from the three independent GO sub-ontologies, that limit the power to provide complex semantic queries and inference services based on it. 2) The term-centric view of GO annotation data and the fact that all information is stored in a single file. This makes attempts to retrieve GO annotations based on big volume datasets unmanageable. 3) No support of GOSlim.RESULTS:We propose a RDF model, GORouter, which encodes heterogeneous original data in a uniform RDF format, creates additional ontology mappings between GO terms, and introduces a set of inference rulebases. Furthermore, we use the Oracle Network Data Model (NDM) as the native RDF data repository and the table function RDF\_MATCH to seamlessly combine the result of RDF queries with traditional relational data. As a result, the scale of GORouter is minimized; information not directly involved in semantic inference is put into relational tables.CONCLUSION:Our work demonstrates how to use multiple semantic web tools and techniques to provide a mixture of semantic query and inference solutions of GO and its associations. GORouter is licensed under Apache License Version 2.0, and is accessible via the website: http://www.scbit.org/gorouter/.}, author = {Xu, Qingwei and Shi, Yixiang and Lu, Qiang and Zhang, Guoqing and Luo, Qingming and Li, Yixue }, citeulike-article-id = {2587504}, doi = {10.1186/1471-2105-9-S1-S6}, journal = {BMC Bioinformatics}, keywords = {gene, go, ontology, prediction, rdf, semantic}, number = {Suppl 1}, posted-at = {2008-03-25 19:23:35}, priority = {4}, title = {GORouter: an RDF model for providing semantic query and inference services for Gene Ontology and its associations}, url = {http://dx.doi.org/10.1186/1471-2105-9-S1-S6}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2587504 L3 - citeulike-article-id:2587504 TI - GORouter: an RDF model for providing semantic query and inference services for Gene Ontology and its associations JF - BMC Bioinformatics VL - 9 IS - Suppl 1 N2 - BACKGROUND:The most renowned biological ontology, Gene Ontology (GO) is widely used for annotations of genes and gene products of different organisms. However, there are shortcomings in the Resource Description Framework (RDF) data file provided by the GO consortium: 1) Lack of sufficient semantic relationships between pairs of terms coming from the three independent GO sub-ontologies, that limit the power to provide complex semantic queries and inference services based on it. 2) The term-centric view of GO annotation data and the fact that all information is stored in a single file. This makes attempts to retrieve GO annotations based on big volume datasets unmanageable. 3) No support of GOSlim.RESULTS:We propose a RDF model, GORouter, which encodes heterogeneous original data in a uniform RDF format, creates additional ontology mappings between GO terms, and introduces a set of inference rulebases. Furthermore, we use the Oracle Network Data Model (NDM) as the native RDF data repository and the table function RDF_MATCH to seamlessly combine the result of RDF queries with traditional relational data. As a result, the scale of GORouter is minimized; information not directly involved in semantic inference is put into relational tables.CONCLUSION:Our work demonstrates how to use multiple semantic web tools and techniques to provide a mixture of semantic query and inference solutions of GO and its associations. GORouter is licensed under Apache License Version 2.0, and is accessible via the website: http://www.scbit.org/gorouter/. KW - gene KW - go KW - ontology KW - prediction KW - rdf KW - semantic AU - Xu, Qingwei AU - Shi, Yixiang AU - Lu, Qiang AU - Zhang, Guoqing AU - Luo, Qingming AU - Li, Yixue PY - 2008/// UR - http://dx.doi.org/10.1186/1471-2105-9-S1-S6 ER -