Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window

@article{citeulike:1179028, abstract = {Cellular competence is an essential but poorly understood aspect of development. Is competence a general property that affects multiple signaling pathways (e.g., chromatin state), or is competence specific for each signaling pathway (e.g., availability of cofactors)? Here we find that Drosophila neuroblast 7-1 (NB7-1) has a single early window of competence to respond to four different temporal identity genes (Hunchback, Kruppel, Pdm, and Castor); that each of these factors specifies distinct motor neuron identities within this competence window but not outside it; and that progressive restriction to respond to Hunchback and Kruppel occurs within this window. Our work raises the possibility that multiple competence windows may allow the same factors to generate different cell types within the same lineage. 10.1101/gad.1382206}, author = {Cleary, Michael D. and Doe, Chris Q. }, citeulike-article-id = {1179028}, journal = {Genes Dev.}, keywords = {competence, development, drosophila, neuroblasts}, month = {February}, number = {4}, pages = {429--434}, posted-at = {2007-03-21 12:20:03}, priority = {5}, title = {Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window}, url = {http://www.genesdev.org/cgi/content/abstract/20/4/429}, volume = {20}, year = {2006} }

TY - JOUR ID - citeulike:1179028 L3 - citeulike-article-id:1179028 TI - Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window JF - Genes Dev. VL - 20 IS - 4 SP - 429 EP - 434 N2 - Cellular competence is an essential but poorly understood aspect of development. Is competence a general property that affects multiple signaling pathways (e.g., chromatin state), or is competence specific for each signaling pathway (e.g., availability of cofactors)? Here we find that Drosophila neuroblast 7-1 (NB7-1) has a single early window of competence to respond to four different temporal identity genes (Hunchback, Kruppel, Pdm, and Castor); that each of these factors specifies distinct motor neuron identities within this competence window but not outside it; and that progressive restriction to respond to Hunchback and Kruppel occurs within this window. Our work raises the possibility that multiple competence windows may allow the same factors to generate different cell types within the same lineage. 10.1101/gad.1382206 KW - competence KW - development KW - drosophila KW - neuroblasts AU - Cleary, Michael AU - Doe, Chris PY - 2006/02/15/ UR - http://www.genesdev.org/cgi/content/abstract/20/4/429 ER -