Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex.

@article{citeulike:548080, abstract = {Typically, D1 and D2 dopamine (DA) receptors exert opposing actions on intracellular signaling molecules and often have disparate physiological effects; however, the factors determining preferential activation of D1 versus D2 signaling are not clear. Here, in vitro patch-clamp recordings show that DA concentration is a critical determinant of D1 versus D2 signaling in prefrontal cortex (PFC). Low DA concentrations (<500 nm) enhance IPSCs via D1 receptors, protein kinase A, and cAMP. Higher DA concentrations (>1 microm) decrease IPSCs via the following cascade: D2-->G(i)-->platelet-derived growth factor receptor--> increase phospholipase C--> increase IP3--> increase Ca2+--> decrease dopamine and cAMP-regulated phosphoprotein-32--> increase protein phosphatase 1/2A--> decrease GABA(A). Blockade of any molecule in the D2-linked pathway reveals a D1-mediated increase in IPSCs, suggesting that D1 effects are occluded at higher DA concentrations by this D2-mediated pathway. Thus, DA concentration, by acting through separate signaling cascades, may determine the relative amount of cortical inhibition and thereby differentially regulate the tuning of cortical networks.}, address = {Physiology and Neuroscience Department, Medical University of South Carolina, Charleston, South Carolina 29425, USA.}, author = {Trantham-Davidson, H. and Neely, L. C. and Lavin, A. and Seamans, J. K. }, citeulike-article-id = {548080}, doi = {10.1523/JNEUROSCI.3179-04.2004}, issn = {1529-2401}, journal = {J Neurosci}, keywords = {d1, d2, dopamine, inhibition, invitro, pfc}, month = {November}, number = {47}, pages = {10652--10659}, posted-at = {2007-06-10 20:23:00}, priority = {2}, title = {Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.3179-04.2004}, volume = {24}, year = {2004} }

TY - JOUR ID - citeulike:548080 L3 - citeulike-article-id:548080 TI - Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex. JF - J Neurosci VL - 24 IS - 47 SP - 10652 EP - 10659 AD - Physiology and Neuroscience Department, Medical University of South Carolina, Charleston, South Carolina 29425, USA. SN - 1529-2401 N2 - Typically, D1 and D2 dopamine (DA) receptors exert opposing actions on intracellular signaling molecules and often have disparate physiological effects; however, the factors determining preferential activation of D1 versus D2 signaling are not clear. Here, in vitro patch-clamp recordings show that DA concentration is a critical determinant of D1 versus D2 signaling in prefrontal cortex (PFC). Low DA concentrations (<500 nm) enhance IPSCs via D1 receptors, protein kinase A, and cAMP. Higher DA concentrations (>1 microm) decrease IPSCs via the following cascade: D2-->G(i)-->platelet-derived growth factor receptor--> increase phospholipase C--> increase IP3--> increase Ca2+--> decrease dopamine and cAMP-regulated phosphoprotein-32--> increase protein phosphatase 1/2A--> decrease GABA(A). Blockade of any molecule in the D2-linked pathway reveals a D1-mediated increase in IPSCs, suggesting that D1 effects are occluded at higher DA concentrations by this D2-mediated pathway. Thus, DA concentration, by acting through separate signaling cascades, may determine the relative amount of cortical inhibition and thereby differentially regulate the tuning of cortical networks. KW - d1 KW - d2 KW - dopamine KW - inhibition KW - invitro KW - pfc AU - Trantham-Davidson, H AU - Neely, LC AU - Lavin, A AU - Seamans, JK PY - 2004/11/24/ UR - http://dx.doi.org/10.1523/JNEUROSCI.3179-04.2004 ER -