Feedforward Excitation and Inhibition Evoke Dual Modes of Firing in the Cat's Visual Thalamus during Naturalistic Viewing

@article{citeulike:1530686, abstract = {Summary Thalamic relay cells transmit information from retina to cortex by firing either rapid bursts or tonic trains of spikes. Bursts occur when the membrane voltage is low, as during sleep, because they depend on channels that cannot respond to excitatory input unless they are primed by strong hyperpolarization. Cells fire tonically when depolarized, as during waking. Thus, mode of firing is usually associated with behavioral state. Growing evidence, however, suggests that sensory processing involves both burst and tonic spikes. To ask if visually evoked synaptic responses induce each type of firing, we recorded intracellular responses to natural movies from relay cells and developed methods to map the receptive fields of the excitation and inhibition that the images evoked. In addition to tonic spikes, the movies routinely elicited lasting inhibition from the center of the receptive field that permitted bursts to fire. Therefore, naturally evoked patterns of synaptic input engage dual modes of firing.}, author = {Wang, Xin and Wei, Yichun and Vaingankar, Vishal and Wang, Qingbo and Koepsell, Kilian and Sommer, Friedrich T. and Hirsch, Judith A. }, citeulike-article-id = {1530686}, doi = {http://dx.doi.org/10.1016/j.neuron.2007.06.039}, journal = {Neuron}, keywords = {bursting, firing\_patterns, inhibition, lgn, neural\_coding, vision}, month = {August}, number = {3}, pages = {465--478}, posted-at = {2008-07-07 16:21:09}, priority = {2}, title = {Feedforward Excitation and Inhibition Evoke Dual Modes of Firing in the Cat's Visual Thalamus during Naturalistic Viewing}, url = {http://dx.doi.org/10.1016/j.neuron.2007.06.039}, volume = {55}, year = {2007} }

TY - JOUR ID - citeulike:1530686 L3 - citeulike-article-id:1530686 TI - Feedforward Excitation and Inhibition Evoke Dual Modes of Firing in the Cat's Visual Thalamus during Naturalistic Viewing JF - Neuron VL - 55 IS - 3 SP - 465 EP - 478 N2 - Summary Thalamic relay cells transmit information from retina to cortex by firing either rapid bursts or tonic trains of spikes. Bursts occur when the membrane voltage is low, as during sleep, because they depend on channels that cannot respond to excitatory input unless they are primed by strong hyperpolarization. Cells fire tonically when depolarized, as during waking. Thus, mode of firing is usually associated with behavioral state. Growing evidence, however, suggests that sensory processing involves both burst and tonic spikes. To ask if visually evoked synaptic responses induce each type of firing, we recorded intracellular responses to natural movies from relay cells and developed methods to map the receptive fields of the excitation and inhibition that the images evoked. In addition to tonic spikes, the movies routinely elicited lasting inhibition from the center of the receptive field that permitted bursts to fire. Therefore, naturally evoked patterns of synaptic input engage dual modes of firing. KW - bursting KW - firing_patterns KW - inhibition KW - lgn KW - neural_coding KW - vision AU - Wang, Xin AU - Wei, Yichun AU - Vaingankar, Vishal AU - Wang, Qingbo AU - Koepsell, Kilian AU - Sommer, Friedrich AU - Hirsch, Judith PY - 2007/08/02/ UR - http://dx.doi.org/10.1016/j.neuron.2007.06.039 ER -